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- Cufflinks assembles transcripts, estimates their abundances, and tests
- for differential expression and regulation in RNA-Seq samples. It
- accepts aligned RNA-Seq reads and assembles the alignments into a
- parsimonious set of transcripts. Cufflinks then estimates the relative
- abundances of these transcripts based on how many reads support each
- one, taking into account biases in library preparation protocols.
- Cufflinks is a collaborative effort between the Laboratory for
- Mathematical and Computational Biology, led by Lior Pachter at UC
- Berkeley, Steven Salzberg's computational genomics group at the
- Institute of Genetic Medicine at Johns Hopkins University, and Barbara
- Wold's lab at Caltech.
- Reference:
- Ali Mortazavi, Brian A Williams, Kenneth McCue, Lorian Schaeffer and
- Barbara Wold, "Mapping and quantifying mammalian transcriptomes by
- RNA-Seq", Nature Methods, volume 5, 621 - 628 (2008)
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