chem.md 3.9 KB
BioChemistry
- Amino acids
- Proteinogenic amino acid
- http://en.wikipedia.org/wiki/Selenocysteine
- http://en.wikipedia.org/wiki/Pyrrolysine
Quantum Chemistry
Chemical Bonding
- http://en.wikipedia.org/wiki/Divalent {Ref: http://en.wikipedia.org/wiki/Prokaryotic_DNA_replication}
- http://en.wikipedia.org/wiki/Electron
- http://en.wikipedia.org/wiki/Phosphate
- http://en.wikipedia.org/wiki/Van_der_Waals_force
- Molecular dipoles formed during the process of Prokaryotic DNA replication
Quantum Field Theory
- https://en.wikipedia.org/wiki/Dirac_equation
- https://en.wikipedia.org/wiki/Schr%C3%B6dinger_equation
1) Call from the NIH on "Big Data to Knowledge (BD2K) Advancing Biomedical Science Using Crowdsourcing and Interactive Digital Media"
http://grants.nih.gov/grants/guide/rfa-files/RFA-CA-15-006.html
2) The NIH screen for known drugs showing promise vs Ebola, featuring John McKew
http://www.nature.com/emi/journal/v3/n12/full/emi201488a.html
3) Whole issue of Chem Rev on neglected disease drug discovery
http://pubs.acs.org/doi/abs/10.1021/cr500546h
4) "The Drugs for Neglected Diseases initiative (DNDi) has been awarded US$ 10 million by the United States Agency for International Development (USAID) to develop new treatments for onchocerciasis (river blindness) and lymphatic filariasis (elephantiasis) - the first-ever USAID grant for neglected tropical disease research and development (R&D)."
5) Articles from NRDD in 2014 making claim that pharma R&D productivity is "on the comeback trail"
http://www.nature.com/nrd/journal/v13/n5/full/nrd4320.html
and that precompetitive research is important
http://www.nature.com/nrd/journal/v13/n2/full/nrd4230.html
and the state of UK academic drug discovery
http://www.nature.com/nrd/journal/v13/n1/full/nrd4200.html
and article on the proposed Human Vaccines Project
http://www.nature.com/nrd/journal/v14/n1/full/nrd4528.html
a feature/retrospective of Bayer's Grants4Targets open innovation scheme and the possible use of "delinkage" strategies in the funding of antibiotic drug discovery R&D and an interesting recent postmortem on the results of Bayer donating compounds to external collaborators: "Remarkably, the interactions within this compound-donation programme had a positive influence on the recipient's opinion of both pharmaceutical research in general and of Bayer in particular."
6) Proposal to extend drug patent lifetimes by a year and reinvest funds in e.g. the NIH :: http://www.nature.com/nrd/journal/v14/n2/full/nrd4454-c1.html And as a counterpoint there was a WashPo article on "Why patents are innovation's worst enemy"
7) Report from the Institute of Medicine on "Sharing Clinical Trial Data: Maximizing Benefits, Minimizing Risk":: http://www.iom.edu/Reports/2015/Sharing-Clinical-Trial-Data.aspx
8) Thinklab - an initiative that uses project funds to pay for contributions to open projects, an interesting idea fraught with risks that is worth exploring (my view)
9) A recent John Oliver piece on the practice of marketing to doctors :: https://www.youtube.com/watch?v=YQZ2UeOTO3I