Halaman utama Jelajahi Bantuan
Masuk
mooigraph
/
qtgraphml
Liatin 1
Bintangi 0
Fork 0
Berkas Masalah 0 Tarik Permintaan 0 Wiki
Cabang: master
Ranting Tag
qtgraphml
/
original
/
Samples
/
SBML_files
/
BIOMD0000000237.xml

BIOMD0000000237.xml 76 KB
Permalink Riwayat Mentahan

1234567891011121314151617181920212223242526272829303132333435363738394041424344454647484950515253545556575859606162636465666768697071727374757677787980818283848586878889909192939495969798991001011021031041051061071081091101111121131141151161171181191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622632642652662672682692702712722732742752762772782792802812822832842852862872882892902912922932942952962972982993003013023033043053063073083093103113123133143153163173183193203213223233243253263273283293303313323333343353363373383393403413423433443453463473483493503513523533543553563573583593603613623633643653663673683693703713723733743753763773783793803813823833843853863873883893903913923933943953963973983994004014024034044054064074084094104114124134144154164174184194204214224234244254264274284294304314324334344354364374384394404414424434444454464474484494504514524534544554564574584594604614624634644654664674684694704714724734744754764774784794804814824834844854864874884894904914924934944954964974984995005015025035045055065075085095105115125135145155165175185195205215225235245255265275285295305315325335345355365375385395405415425435445455465475485495505515525535545555565575585595605615625635645655665675685695705715725735745755765775785795805815825835845855865875885895905915925935945955965975985996006016026036046056066076086096106116126136146156166176186196206216226236246256266276286296306316326336346356366376386396406416426436446456466476486496506516526536546556566576586596606616626636646656666676686696706716726736746756766776786796806816826836846856866876886896906916926936946956966976986997007017027037047057067077087097107117127137147157167177187197207217227237247257267277287297307317327337347357367377387397407417427437447457467477487497507517527537547557567577587597607617627637647657667677687697707717727737747757767777787797807817827837847857867877887897907917927937947957967977987998008018028038048058068078088098108118128138148158168178188198208218228238248258268278288298308318328338348358368378388398408418428438448458468478488498508518528538548558568578588598608618628638648658668678688698708718728738748758768778788798808818828838848858868878888898908918928938948958968978988999009019029039049059069079089099109119129139149159169179189199209219229239249259269279289299309319329339349359369379389399409419429439449459469479489499509519529539549559569579589599609619629639649659669679689699709719729739749759769779789799809819829839849859869879889899909919929939949959969979989991000100110021003100410051006100710081009101010111012101310141015101610171018101910201021102210231024102510261027102810291030103110321033103410351036103710381039104010411042104310441045104610471048104910501051105210531054105510561057105810591060106110621063106410651066106710681069107010711072107310741075107610771078107910801081108210831084108510861087108810891090109110921093109410951096109710981099110011011102110311041105110611071108110911101111111211131114111511161117111811191120112111221123112411251126112711281129113011311132113311341135113611371138113911401141114211431144114511461147114811491150115111521153115411551156115711581159116011611162116311641165116611671168116911701171117211731174117511761177117811791180118111821183118411851186118711881189119011911192119311941195119611971198119912001201120212031204120512061207120812091210121112121213121412151216121712181219122012211222122312241225122612271228122912301231123212331234123512361237123812391240124112421243124412451246124712481249125012511252125312541255125612571258125912601261126212631264126512661267126812691270127112721273127412751276127712781279128012811282128312841285128612871288128912901291129212931294129512961297129812991300130113021303130413051306130713081309131013111312131313141315131613171318131913201321132213231324132513261327132813291330133113321333133413351336133713381339134013411342134313441345134613471348134913501351135213531354135513561357135813591360136113621363136413651366136713681369137013711372137313741375137613771378137913801381138213831384138513861387138813891390139113921393139413951396139713981399140014011402140314041405140614071408140914101411141214131414141514161417141814191420142114221423142414251426142714281429143014311432143314341435143614371438143914401441144214431444144514461447144814491450145114521453145414551456145714581459146014611462146314641465146614671468146914701471147214731474147514761477147814791480148114821483148414851486148714881489149014911492149314941495149614971498149915001501150215031504150515061507150815091510151115121513151415151516151715181519152015211522152315241525152615271528152915301531153215331534153515361537153815391540154115421543154415451546154715481549155015511552155315541555155615571558155915601561156215631564156515661567156815691570157115721573157415751576157715781579158015811582158315841585158615871588158915901591159215931594159515961597159815991600160116021603160416051606160716081609161016111612161316141615161616171618161916201621162216231624162516261627162816291630163116321633163416351636163716381639164016411642164316441645164616471648164916501651165216531654165516561657 
  1. <?xml version='1.0' encoding='UTF-8' standalone='no'?>
    2. 

  2. <sbml xmlns="http://www.sbml.org/sbml/level2/version4" level="2" metaid="metaid_0000001" version="4">
    3. 

  3.   <model id="Schaber2006_Pheromone_Starvation_Crosstalk" name="Schaber2006_Pheromone_Starvation_Crosstalk" metaid="metaid_0000002">
    4. 

  4.     <notes>
    5. 

  5.       <body xmlns="http://www.w3.org/1999/xhtml">
    6. 

  6.         <p>This a model from the article:      <br/>
    7. 

  7.                 <strong>A modelling approach to quantify dynamic crosstalk between the pheromone and the starvation pathway in baker's yeast.</strong>
    8. 

  8.                 <br/>
    9. 

  9.           Schaber J, Kofahl B, Kowald A, Klipp E      <em>FEBS J.</em>
    10. 

  10.           2006 Aug; 273(15):3520-33      <a href="http://www.ncbi.nlm.nih.gov/pubmed/16884493">16884493</a>
    11. 

  11.           ,      <br/>
    12. 

  12.                 <strong>Abstract:</strong>
    13. 

  13.                 <br/>
    14. 

  14.           Cells must be able to process multiple information in parallel and, moreover, they must also be able to combine this information in order to trigger the appropriate response. This is achieved by wiring signalling pathways such that they can interact with each other, a phenomenon often called crosstalk. In this study, we employ mathematical modelling techniques to analyse dynamic mechanisms and measures of crosstalk. We present a dynamic mathematical model that compiles current knowledge about the wiring of the pheromone pathway and the filamentous growth pathway in yeast. We consider the main dynamic features and the interconnections between the two pathways in order to study dynamic crosstalk between these two pathways in haploid cells. We introduce two new measures of dynamic crosstalk, the intrinsic specificity and the extrinsic specificity. These two measures incorporate the combined signal of several stimuli being present simultaneously and seem to be more stable than previous measures. When both pathways are responsive and stimulated, the model predicts that (a) the filamentous growth pathway amplifies the response of the pheromone pathway, and (b) the pheromone pathway inhibits the response of filamentous growth pathway in terms of mitogen activated protein kinase activity and transcriptional activity, respectively. Among several mechanisms we identified leakage of activated Ste11 as the most influential source of crosstalk. Moreover, we propose new experiments and predict their outcomes in order to test hypotheses about the mechanisms of crosstalk between the two pathways. Studying signals that are transmitted in parallel gives us new insights about how pathways and signals interact in a dynamical way, e.g., whether they amplify, inhibit, delay or accelerate each other.      </p>
    15. 

  15.             <p>This model originates from BioModels Database: A Database of Annotated Published Models. It is copyright (c) 2005-2009 The BioModels Team.      <br/>
    16. 

  16.           For more information see the      <a href="http://www.ebi.ac.uk/biomodels/legal.html" target="_blank">terms of use</a>
    17. 

  17.           .      <br/>
    18. 

  18.           To cite BioModels Database, please use      <a href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&amp;pubmedid=16381960" target="_blank">Le Novère N., Bornstein B., Broicher A., Courtot M., Donizelli M., Dharuri H., Li L., Sauro H., Schilstra M., Shapiro B., Snoep J.L., Hucka M. (2006) BioModels Database: A Free, Centralized Database of Curated, Published, Quantitative Kinetic Models of Biochemical and Cellular Systems Nucleic Acids Res., 34: D689-D691.</a>
    19. 

  19.                 </p>
    20. 

  20.             </body>
    21. 

  21.       
    22. 

  22.     </notes>
    23. 

  23.     <annotation>
    24. 

  24.       <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
    25. 

  25.         <rdf:Description rdf:about="#metaid_0000002">
    26. 

  26.           <dc:creator>
    27. 

  27.             <rdf:Bag>
    28. 

  28.               <rdf:li rdf:parseType="Resource">
    29. 

  29.                 <vCard:N rdf:parseType="Resource">
    30. 

  30.                   <vCard:Family>Endler</vCard:Family>
    31. 

  31.                   <vCard:Given>Lukas</vCard:Given>
    32. 

  32.                 </vCard:N>
    33. 

  33.                 <vCard:EMAIL>lukas@ebi.ac.uk</vCard:EMAIL>
    34. 

  34.                 <vCard:ORG rdf:parseType="Resource">
    35. 

  35.                   <vCard:Orgname>EMBL-EBI</vCard:Orgname>
    36. 

  36.                 </vCard:ORG>
    37. 

  37.               </rdf:li>
    38. 

  38.               <rdf:li rdf:parseType="Resource">
    39. 

  39.                 <vCard:N rdf:parseType="Resource">
    40. 

  40.                   <vCard:Family>Chelliah</vCard:Family>
    41. 

  41.                   <vCard:Given>Vijayalakshmi</vCard:Given>
    42. 

  42.                 </vCard:N>
    43. 

  43.                 <vCard:EMAIL>viji@ebi.ac.uk</vCard:EMAIL>
    44. 

  44.                 <vCard:ORG rdf:parseType="Resource">
    45. 

  45.                   <vCard:Orgname>EMBL-EBI</vCard:Orgname>
    46. 

  46.                 </vCard:ORG>
    47. 

  47.               </rdf:li>
    48. 

  48.               <rdf:li rdf:parseType="Resource">
    49. 

  49.                 <vCard:N rdf:parseType="Resource">
    50. 

  50.                   <vCard:Family>Schaber</vCard:Family>
    51. 

  51.                   <vCard:Given>Jorg</vCard:Given>
    52. 

  52.                 </vCard:N>
    53. 

  53.                 <vCard:EMAIL>schaber@molgen.mpg.de</vCard:EMAIL>
    54. 

  54.                 <vCard:ORG rdf:parseType="Resource">
    55. 

  55.                   <vCard:Orgname>Max Planck Institute for Molecular Genetics, Computational Systems Biology Group, Germany.</vCard:Orgname>
    56. 

  56.                 </vCard:ORG>
    57. 

  57.               </rdf:li>
    58. 

  58.             </rdf:Bag>
    59. 

  59.           </dc:creator>
    60. 

  60.           <dcterms:created rdf:parseType="Resource">
    61. 

  61.             <dcterms:W3CDTF>2009-08-20T17:18:13Z</dcterms:W3CDTF>
    62. 

  62.           </dcterms:created>
    63. 

  63.           <dcterms:modified rdf:parseType="Resource">
    64. 

  64.             <dcterms:W3CDTF>2011-09-08T11:27:23Z</dcterms:W3CDTF>
    65. 

  65.           </dcterms:modified>
    66. 

  66.           <bqmodel:is>
    67. 

  67.             <rdf:Bag>
    68. 

  68.               <rdf:li rdf:resource="http://identifiers.org/biomodels.db/MODEL5952001443"/>
    69. 

  69.             </rdf:Bag>
    70. 

  70.           </bqmodel:is>
    71. 

  71.           <bqmodel:is>
    72. 

  72.             <rdf:Bag>
    73. 

  73.               <rdf:li rdf:resource="http://identifiers.org/biomodels.db/BIOMD0000000237"/>
    74. 

  74.             </rdf:Bag>
    75. 

  75.           </bqmodel:is>
    76. 

  76.           <bqmodel:isDescribedBy>
    77. 

  77.             <rdf:Bag>
    78. 

  78.               <rdf:li rdf:resource="http://identifiers.org/pubmed/16884493"/>
    79. 

  79.             </rdf:Bag>
    80. 

  80.           </bqmodel:isDescribedBy>
    81. 

  81.           <bqbiol:occursIn>
    82. 

  82.             <rdf:Bag>
    83. 

  83.               <rdf:li rdf:resource="http://identifiers.org/taxonomy/4932"/>
    84. 

  84.             </rdf:Bag>
    85. 

  85.           </bqbiol:occursIn>
    86. 

  86.           <bqbiol:hasVersion>
    87. 

  87.             <rdf:Bag>
    88. 

  88.               <rdf:li rdf:resource="http://identifiers.org/obo.go/GO:0042810"/>
    89. 

  89.               <rdf:li rdf:resource="http://identifiers.org/obo.go/GO:0010570"/>
    90. 

  90.             </rdf:Bag>
    91. 

  91.           </bqbiol:hasVersion>
    92. 

  92.         </rdf:Description>
    93. 

  93.       </rdf:RDF>
    94. 

  94.     </annotation>
    95. 

  95.       <listOfCompartments>
    96. 

  96.       <compartment id="compartment" name="compartment" metaid="metaid_0000049" sboTerm="SBO:0000290" size="1">
    97. 

  97.         <annotation>
    98. 

  98.           <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
    99. 

  99.             <rdf:Description rdf:about="#metaid_0000049">
    100. 

  100.               <bqmodel:is>
    101. 

  101.                 <rdf:Bag>
    102. 

  102.                   <rdf:li rdf:resource="http://identifiers.org/obo.go/GO:0005623"/>
    103. 

  103.                 </rdf:Bag>
    104. 

  104.               </bqmodel:is>
    105. 

  105.             </rdf:Description>
    106. 

  106.           </rdf:RDF>
    107. 

  107.         </annotation>
    108. 

  108.       </compartment>
    109. 

  109.     </listOfCompartments>
    110. 

  110.     <listOfSpecies>
    111. 

  111.       <species id="Ste5" initialConcentration="42.3" name="Ste5" metaid="metaid_0000050" sboTerm="SBO:0000252" compartment="compartment">
    112. 

  112.         <annotation>
    113. 

  113.           <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
    114. 

  114.             <rdf:Description rdf:about="#metaid_0000050">
    115. 

  115.               <bqbiol:isVersionOf>
    116. 

  116.                 <rdf:Bag>
    117. 

  117.                   <rdf:li rdf:resource="http://identifiers.org/uniprot/P32917"/>
    118. 

  118.                 </rdf:Bag>
    119. 

  119.               </bqbiol:isVersionOf>
    120. 

  120.               <bqbiol:hasProperty>
    121. 

  121.                 <rdf:Bag>
    122. 

  122.                   <rdf:li rdf:resource="http://identifiers.org/obo.go/GO:0005078"/>
    123. 

  123.                 </rdf:Bag>
    124. 

  124.               </bqbiol:hasProperty>
    125. 

  125.             </rdf:Description>
    126. 

  126.           </rdf:RDF>
    127. 

  127.         </annotation>
    128. 

  128.       </species>
    129. 

  129.       <species id="Ste11" initialConcentration="13.3" name="Ste11" metaid="metaid_0000051" sboTerm="SBO:0000252" compartment="compartment">
    130. 

  130.         <annotation>
    131. 

  131.           <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
    132. 

  132.             <rdf:Description rdf:about="#metaid_0000051">
    133. 

  133.               <bqbiol:isVersionOf>
    134. 

  134.                 <rdf:Bag>
    135. 

  135.                   <rdf:li rdf:resource="http://identifiers.org/uniprot/P23561"/>
    136. 

  136.                 </rdf:Bag>
    137. 

  137.               </bqbiol:isVersionOf>
    138. 

  138.               <bqbiol:hasProperty>
    139. 

  139.                 <rdf:Bag>
    140. 

  140.                   <rdf:li rdf:resource="http://identifiers.org/obo.go/GO:0004709"/>
    141. 

  141.                 </rdf:Bag>
    142. 

  142.               </bqbiol:hasProperty>
    143. 

  143.             </rdf:Description>
    144. 

  144.           </rdf:RDF>
    145. 

  145.         </annotation>
    146. 

  146.       </species>
    147. 

  147.       <species id="Ste5Ste11" initialConcentration="5.6" name="Ste5Ste11" metaid="metaid_0000052" sboTerm="SBO:0000297" compartment="compartment">
    148. 

  148.         <annotation>
    149. 

  149.           <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
    150. 

  150.             <rdf:Description rdf:about="#metaid_0000052">
    151. 

  151.               <bqbiol:hasPart>
    152. 

  152.                 <rdf:Bag>
    153. 

  153.                   <rdf:li rdf:resource="http://identifiers.org/uniprot/P23561"/>
    154. 

  154.                   <rdf:li rdf:resource="http://identifiers.org/uniprot/P32917"/>
    155. 

  155.                 </rdf:Bag>
    156. 

  156.               </bqbiol:hasPart>
    157. 

  157.             </rdf:Description>
    158. 

  158.           </rdf:RDF>
    159. 

  159.         </annotation>
    160. 

  160.       </species>
    161. 

  161.       <species id="Gbg" initialConcentration="53" name="Gbg" metaid="metaid_0000053" sboTerm="SBO:0000252" compartment="compartment">
    162. 

  162.         <annotation>
    163. 

  163.           <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
    164. 

  164.             <rdf:Description rdf:about="#metaid_0000053">
    165. 

  165.               <bqbiol:hasPart>
    166. 

  166.                 <rdf:Bag>
    167. 

  167.                   <rdf:li rdf:resource="http://identifiers.org/uniprot/A6ZP55"/>
    168. 

  168.                   <rdf:li rdf:resource="http://identifiers.org/uniprot/P53130"/>
    169. 

  169.                 </rdf:Bag>
    170. 

  170.               </bqbiol:hasPart>
    171. 

  171.             </rdf:Description>
    172. 

  172.           </rdf:RDF>
    173. 

  173.         </annotation>
    174. 

  174.       </species>
    175. 

  175.       <species id="Ste5Ste11Gbg" initialConcentration="0" name="Ste5Ste11Gbg" metaid="metaid_0000054" sboTerm="SBO:0000297" compartment="compartment">
    176. 

  176.         <annotation>
    177. 

  177.           <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
    178. 

  178.             <rdf:Description rdf:about="#metaid_0000054">
    179. 

  179.               <bqbiol:hasPart>
    180. 

  180.                 <rdf:Bag>
    181. 

  181.                   <rdf:li rdf:resource="http://identifiers.org/uniprot/P53130"/>
    182. 

  182.                   <rdf:li rdf:resource="http://identifiers.org/uniprot/A6ZP55"/>
    183. 

  183.                   <rdf:li rdf:resource="http://identifiers.org/uniprot/P32917"/>
    184. 

  184.                   <rdf:li rdf:resource="http://identifiers.org/uniprot/P23561"/>
    185. 

  185.                 </rdf:Bag>
    186. 

  186.               </bqbiol:hasPart>
    187. 

  187.             </rdf:Description>
    188. 

  188.           </rdf:RDF>
    189. 

  189.         </annotation>
    190. 

  190.       </species>
    191. 

  191.       <species id="Fus3" initialConcentration="217" name="Fus3" metaid="metaid_0000055" sboTerm="SBO:0000252" compartment="compartment">
    192. 

  192.         <annotation>
    193. 

  193.           <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
    194. 

  194.             <rdf:Description rdf:about="#metaid_0000055">
    195. 

  195.               <bqbiol:isVersionOf>
    196. 

  196.                 <rdf:Bag>
    197. 

  197.                   <rdf:li rdf:resource="http://identifiers.org/uniprot/P16892"/>
    198. 

  198.                 </rdf:Bag>
    199. 

  199.               </bqbiol:isVersionOf>
    200. 

  200.             </rdf:Description>
    201. 

  201.           </rdf:RDF>
    202. 

  202.         </annotation>
    203. 

  203.       </species>
    204. 

  204.       <species id="Ste5Ste11GbgFus3" initialConcentration="0" name="Ste5Ste11GbgFus3" metaid="metaid_0000056" sboTerm="SBO:0000297" compartment="compartment">
    205. 

  205.         <annotation>
    206. 

  206.           <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
    207. 

  207.             <rdf:Description rdf:about="#metaid_0000056">
    208. 

  208.               <bqbiol:hasPart>
    209. 

  209.                 <rdf:Bag>
    210. 

  210.                   <rdf:li rdf:resource="http://identifiers.org/uniprot/P32917"/>
    211. 

  211.                   <rdf:li rdf:resource="http://identifiers.org/uniprot/P23561"/>
    212. 

  212.                   <rdf:li rdf:resource="http://identifiers.org/uniprot/A6ZP55"/>
    213. 

  213.                   <rdf:li rdf:resource="http://identifiers.org/uniprot/P53130"/>
    214. 

  214.                   <rdf:li rdf:resource="http://identifiers.org/uniprot/P16892"/>
    215. 

  215.                 </rdf:Bag>
    216. 

  216.               </bqbiol:hasPart>
    217. 

  217.             </rdf:Description>
    218. 

  218.           </rdf:RDF>
    219. 

  219.         </annotation>
    220. 

  220.       </species>
    221. 

  221.       <species id="Ste5Ste11GbgFus3P" initialConcentration="0" name="Ste5Ste11GbgFus3P" metaid="metaid_0000057" sboTerm="SBO:0000297" compartment="compartment">
    222. 

  222.         <annotation>
    223. 

  223.           <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
    224. 

  224.             <rdf:Description rdf:about="#metaid_0000057">
    225. 

  225.               <bqbiol:hasPart>
    226. 

  226.                 <rdf:Bag>
    227. 

  227.                   <rdf:li rdf:resource="http://identifiers.org/uniprot/P32917"/>
    228. 

  228.                   <rdf:li rdf:resource="http://identifiers.org/uniprot/P23561"/>
    229. 

  229.                   <rdf:li rdf:resource="http://identifiers.org/uniprot/A6ZP55"/>
    230. 

  230.                   <rdf:li rdf:resource="http://identifiers.org/uniprot/P53130"/>
    231. 

  231.                   <rdf:li rdf:resource="http://identifiers.org/uniprot/P16892"/>
    232. 

  232.                 </rdf:Bag>
    233. 

  233.               </bqbiol:hasPart>
    234. 

  234.             </rdf:Description>
    235. 

  235.           </rdf:RDF>
    236. 

  236.         </annotation>
    237. 

  237.       </species>
    238. 

  238.       <species id="Fus3PP" initialConcentration="0" name="Fus3PP" metaid="metaid_0000058" sboTerm="SBO:0000252" compartment="compartment">
    239. 

  239.         <annotation>
    240. 

  240.           <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
    241. 

  241.             <rdf:Description rdf:about="#metaid_0000058">
    242. 

  242.               <bqbiol:isVersionOf>
    243. 

  243.                 <rdf:Bag>
    244. 

  244.                   <rdf:li rdf:resource="http://identifiers.org/uniprot/P16892"/>
    245. 

  245.                 </rdf:Bag>
    246. 

  246.               </bqbiol:isVersionOf>
    247. 

  247.               <bqbiol:hasProperty>
    248. 

  248.                 <rdf:Bag>
    249. 

  249.                   <rdf:li rdf:resource="http://identifiers.org/obo.go/GO:0004707"/>
    250. 

  250.                 </rdf:Bag>
    251. 

  251.               </bqbiol:hasProperty>
    252. 

  252.             </rdf:Description>
    253. 

  253.           </rdf:RDF>
    254. 

  254.         </annotation>
    255. 

  255.       </species>
    256. 

  256.       <species id="Ste5Ste11GbgP" initialConcentration="0" name="Ste5Ste11GbgP" metaid="metaid_0000059" sboTerm="SBO:0000297" compartment="compartment">
    257. 

  257.         <annotation>
    258. 

  258.           <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
    259. 

  259.             <rdf:Description rdf:about="#metaid_0000059">
    260. 

  260.               <bqbiol:hasPart>
    261. 

  261.                 <rdf:Bag>
    262. 

  262.                   <rdf:li rdf:resource="http://identifiers.org/uniprot/P32917"/>
    263. 

  263.                   <rdf:li rdf:resource="http://identifiers.org/uniprot/P23561"/>
    264. 

  264.                   <rdf:li rdf:resource="http://identifiers.org/uniprot/A6ZP55"/>
    265. 

  265.                   <rdf:li rdf:resource="http://identifiers.org/uniprot/P53130"/>
    266. 

  266.                 </rdf:Bag>
    267. 

  267.               </bqbiol:hasPart>
    268. 

  268.             </rdf:Description>
    269. 

  269.           </rdf:RDF>
    270. 

  270.         </annotation>
    271. 

  271.       </species>
    272. 

  272.       <species id="Ste11Ubi" initialConcentration="0" name="Ste11Ubi" metaid="metaid_0000060" sboTerm="SBO:0000252" compartment="compartment">
    273. 

  273.         <annotation>
    274. 

  274.           <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
    275. 

  275.             <rdf:Description rdf:about="#metaid_0000060">
    276. 

  276.               <bqbiol:hasPart>
    277. 

  277.                 <rdf:Bag>
    278. 

  278.                   <rdf:li rdf:resource="http://identifiers.org/uniprot/P23561"/>
    279. 

  279.                   <rdf:li rdf:resource="http://identifiers.org/uniprot/P61864"/>
    280. 

  280.                 </rdf:Bag>
    281. 

  281.               </bqbiol:hasPart>
    282. 

  282.             </rdf:Description>
    283. 

  283.           </rdf:RDF>
    284. 

  284.         </annotation>
    285. 

  285.       </species>
    286. 

  286.       <species id="p" initialConcentration="0" constant="true" name="p" metaid="metaid_0000061" boundaryCondition="true" sboTerm="SBO:0000291" compartment="compartment"/>
    287. 

  287.       <species id="Kss1" initialConcentration="54.4" name="Kss1" metaid="metaid_0000062" sboTerm="SBO:0000252" compartment="compartment">
    288. 

  288.         <annotation>
    289. 

  289.           <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
    290. 

  290.             <rdf:Description rdf:about="#metaid_0000062">
    291. 

  291.               <bqbiol:isVersionOf>
    292. 

  292.                 <rdf:Bag>
    293. 

  293.                   <rdf:li rdf:resource="http://identifiers.org/uniprot/P14681"/>
    294. 

  294.                 </rdf:Bag>
    295. 

  295.               </bqbiol:isVersionOf>
    296. 

  296.             </rdf:Description>
    297. 

  297.           </rdf:RDF>
    298. 

  298.         </annotation>
    299. 

  299.       </species>
    300. 

  300.       <species id="Ste5Ste11GbgKss1" initialConcentration="0" name="Ste5Ste11GbgKss1" metaid="metaid_0000063" sboTerm="SBO:0000297" compartment="compartment">
    301. 

  301.         <annotation>
    302. 

  302.           <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
    303. 

  303.             <rdf:Description rdf:about="#metaid_0000063">
    304. 

  304.               <bqbiol:hasPart>
    305. 

  305.                 <rdf:Bag>
    306. 

  306.                   <rdf:li rdf:resource="http://identifiers.org/uniprot/P32917"/>
    307. 

  307.                   <rdf:li rdf:resource="http://identifiers.org/uniprot/P23561"/>
    308. 

  308.                   <rdf:li rdf:resource="http://identifiers.org/uniprot/A6ZP55"/>
    309. 

  309.                   <rdf:li rdf:resource="http://identifiers.org/uniprot/P53130"/>
    310. 

  310.                   <rdf:li rdf:resource="http://identifiers.org/uniprot/P14681"/>
    311. 

  311.                 </rdf:Bag>
    312. 

  312.               </bqbiol:hasPart>
    313. 

  313.             </rdf:Description>
    314. 

  314.           </rdf:RDF>
    315. 

  315.         </annotation>
    316. 

  316.       </species>
    317. 

  317.       <species id="Ste5Ste11GbgKss1P" initialConcentration="0" name="Ste5Ste11GbgKss1P" metaid="metaid_0000064" sboTerm="SBO:0000297" compartment="compartment">
    318. 

  318.         <annotation>
    319. 

  319.           <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
    320. 

  320.             <rdf:Description rdf:about="#metaid_0000064">
    321. 

  321.               <bqbiol:hasPart>
    322. 

  322.                 <rdf:Bag>
    323. 

  323.                   <rdf:li rdf:resource="http://identifiers.org/uniprot/P32917"/>
    324. 

  324.                   <rdf:li rdf:resource="http://identifiers.org/uniprot/P23561"/>
    325. 

  325.                   <rdf:li rdf:resource="http://identifiers.org/uniprot/A6ZP55"/>
    326. 

  326.                   <rdf:li rdf:resource="http://identifiers.org/uniprot/P53130"/>
    327. 

  327.                   <rdf:li rdf:resource="http://identifiers.org/uniprot/P14681"/>
    328. 

  328.                 </rdf:Bag>
    329. 

  329.               </bqbiol:hasPart>
    330. 

  330.             </rdf:Description>
    331. 

  331.           </rdf:RDF>
    332. 

  332.         </annotation>
    333. 

  333.       </species>
    334. 

  334.       <species id="Kss1PP" initialConcentration="0" name="Kss1PP" metaid="metaid_0000065" sboTerm="SBO:0000252" compartment="compartment">
    335. 

  335.         <annotation>
    336. 

  336.           <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
    337. 

  337.             <rdf:Description rdf:about="#metaid_0000065">
    338. 

  338.               <bqbiol:isVersionOf>
    339. 

  339.                 <rdf:Bag>
    340. 

  340.                   <rdf:li rdf:resource="http://identifiers.org/uniprot/P14681"/>
    341. 

  341.                 </rdf:Bag>
    342. 

  342.               </bqbiol:isVersionOf>
    343. 

  343.             </rdf:Description>
    344. 

  344.           </rdf:RDF>
    345. 

  345.         </annotation>
    346. 

  346.       </species>
    347. 

  347.       <species id="Ste11P" initialConcentration="0" name="Ste11P" metaid="metaid_0000066" sboTerm="SBO:0000252" compartment="compartment">
    348. 

  348.         <annotation>
    349. 

  349.           <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
    350. 

  350.             <rdf:Description rdf:about="#metaid_0000066">
    351. 

  351.               <bqbiol:isVersionOf>
    352. 

  352.                 <rdf:Bag>
    353. 

  353.                   <rdf:li rdf:resource="http://identifiers.org/uniprot/P23561"/>
    354. 

  354.                 </rdf:Bag>
    355. 

  355.               </bqbiol:isVersionOf>
    356. 

  356.             </rdf:Description>
    357. 

  357.           </rdf:RDF>
    358. 

  358.         </annotation>
    359. 

  359.       </species>
    360. 

  360.       <species id="Ste12Kss1" initialConcentration="35.9" name="Ste12Kss1" metaid="metaid_0000067" sboTerm="SBO:0000297" compartment="compartment">
    361. 

  361.         <annotation>
    362. 

  362.           <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
    363. 

  363.             <rdf:Description rdf:about="#metaid_0000067">
    364. 

  364.               <bqbiol:hasPart>
    365. 

  365.                 <rdf:Bag>
    366. 

  366.                   <rdf:li rdf:resource="http://identifiers.org/uniprot/P14681"/>
    367. 

  367.                   <rdf:li rdf:resource="http://identifiers.org/uniprot/P13574"/>
    368. 

  368.                 </rdf:Bag>
    369. 

  369.               </bqbiol:hasPart>
    370. 

  370.             </rdf:Description>
    371. 

  371.           </rdf:RDF>
    372. 

  372.         </annotation>
    373. 

  373.       </species>
    374. 

  374.       <species id="Ste12" initialConcentration="0.07" name="Ste12" metaid="metaid_0000068" sboTerm="SBO:0000252" compartment="compartment">
    375. 

  375.         <annotation>
    376. 

  376.           <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
    377. 

  377.             <rdf:Description rdf:about="#metaid_0000068">
    378. 

  378.               <bqbiol:isVersionOf>
    379. 

  379.                 <rdf:Bag>
    380. 

  380.                   <rdf:li rdf:resource="http://identifiers.org/uniprot/P13574"/>
    381. 

  381.                 </rdf:Bag>
    382. 

  382.               </bqbiol:isVersionOf>
    383. 

  383.             </rdf:Description>
    384. 

  384.           </rdf:RDF>
    385. 

  385.         </annotation>
    386. 

  386.       </species>
    387. 

  387.       <species id="Ste12P" initialConcentration="0" name="Ste12P" metaid="metaid_0000069" sboTerm="SBO:0000252" compartment="compartment">
    388. 

  388.         <annotation>
    389. 

  389.           <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
    390. 

  390.             <rdf:Description rdf:about="#metaid_0000069">
    391. 

  391.               <bqbiol:isVersionOf>
    392. 

  392.                 <rdf:Bag>
    393. 

  393.                   <rdf:li rdf:resource="http://identifiers.org/uniprot/P13574"/>
    394. 

  394.                 </rdf:Bag>
    395. 

  395.               </bqbiol:isVersionOf>
    396. 

  396.             </rdf:Description>
    397. 

  397.           </rdf:RDF>
    398. 

  398.         </annotation>
    399. 

  399.       </species>
    400. 

  400.       <species id="s" initialConcentration="0" constant="true" name="s" metaid="metaid_0000070" boundaryCondition="true" sboTerm="SBO:0000291" compartment="compartment"/>
    401. 

  401.       <species id="PREP" initialConcentration="0" name="PREP" metaid="metaid_0000071" sboTerm="SBO:0000406" compartment="compartment">
    402. 

  402.         <annotation>
    403. 

  403.           <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
    404. 

  404.             <rdf:Description rdf:about="#metaid_0000071">
    405. 

  405.               <bqbiol:isPartOf>
    406. 

  406.                 <rdf:Bag>
    407. 

  407.                   <rdf:li rdf:resource="http://identifiers.org/obo.go/GO:0019236"/>
    408. 

  408.                 </rdf:Bag>
    409. 

  409.               </bqbiol:isPartOf>
    410. 

  410.             </rdf:Description>
    411. 

  411.           </rdf:RDF>
    412. 

  412.         </annotation>
    413. 

  413.       </species>
    414. 

  414.       <species id="Ste12TeSte5Kss1" initialConcentration="13.7" name="Ste12TeSte5Kss1" metaid="metaid_0000072" sboTerm="SBO:0000297" compartment="compartment">
    415. 

  415.         <annotation>
    416. 

  416.           <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
    417. 

  417.             <rdf:Description rdf:about="#metaid_0000072">
    418. 

  418.               <bqbiol:hasPart>
    419. 

  419.                 <rdf:Bag>
    420. 

  420.                   <rdf:li rdf:resource="http://identifiers.org/uniprot/P32917"/>
    421. 

  421.                   <rdf:li rdf:resource="http://identifiers.org/uniprot/P14681"/>
    422. 

  422.                   <rdf:li rdf:resource="http://identifiers.org/uniprot/P13574"/>
    423. 

  423.                 </rdf:Bag>
    424. 

  424.               </bqbiol:hasPart>
    425. 

  425.             </rdf:Description>
    426. 

  426.           </rdf:RDF>
    427. 

  427.         </annotation>
    428. 

  428.       </species>
    429. 

  429.       <species id="Ste12TeSte5" initialConcentration="0.25" name="Ste12TeSte5" metaid="metaid_0000073" sboTerm="SBO:0000297" compartment="compartment">
    430. 

  430.         <annotation>
    431. 

  431.           <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
    432. 

  432.             <rdf:Description rdf:about="#metaid_0000073">
    433. 

  433.               <bqbiol:hasPart>
    434. 

  434.                 <rdf:Bag>
    435. 

  435.                   <rdf:li rdf:resource="http://identifiers.org/uniprot/P32917"/>
    436. 

  436.                   <rdf:li rdf:resource="http://identifiers.org/uniprot/P13574"/>
    437. 

  437.                 </rdf:Bag>
    438. 

  438.               </bqbiol:hasPart>
    439. 

  439.             </rdf:Description>
    440. 

  440.           </rdf:RDF>
    441. 

  441.         </annotation>
    442. 

  442.       </species>
    443. 

  443.       <species id="Ste12TeSte5P" initialConcentration="0" name="Ste12TeSte5P" metaid="metaid_0000074" sboTerm="SBO:0000297" compartment="compartment">
    444. 

  444.         <annotation>
    445. 

  445.           <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
    446. 

  446.             <rdf:Description rdf:about="#metaid_0000074">
    447. 

  447.               <bqbiol:hasPart>
    448. 

  448.                 <rdf:Bag>
    449. 

  449.                   <rdf:li rdf:resource="http://identifiers.org/uniprot/P32917"/>
    450. 

  450.                   <rdf:li rdf:resource="http://identifiers.org/uniprot/P13574"/>
    451. 

  451.                 </rdf:Bag>
    452. 

  452.               </bqbiol:hasPart>
    453. 

  453.             </rdf:Description>
    454. 

  454.           </rdf:RDF>
    455. 

  455.         </annotation>
    456. 

  456.       </species>
    457. 

  457.       <species id="FREP" initialConcentration="0" name="FREP" metaid="metaid_0000075" sboTerm="SBO:0000406" compartment="compartment">
    458. 

  458.         <annotation>
    459. 

  459.           <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
    460. 

  460.             <rdf:Description rdf:about="#metaid_0000075">
    461. 

  461.               <bqbiol:isPartOf>
    462. 

  462.                 <rdf:Bag>
    463. 

  463.                   <rdf:li rdf:resource="http://identifiers.org/obo.go/GO:0045311"/>
    464. 

  464.                 </rdf:Bag>
    465. 

  465.               </bqbiol:isPartOf>
    466. 

  466.             </rdf:Description>
    467. 

  467.           </rdf:RDF>
    468. 

  468.         </annotation>
    469. 

  469.       </species>
    470. 

  470.     </listOfSpecies>
    471. 

  471.     <listOfParameters>
    472. 

  472.       <parameter id="alpha" constant="false" metaid="metaid_0000003"/>
    473. 

  473.       <parameter id="beta" constant="false" metaid="metaid_0000004"/>
    474. 

  474.       <parameter id="alphaA" name="alphaA" metaid="metaid_0000005" value="1"/>
    475. 

  475.       <parameter id="betaA" name="betaA" metaid="metaid_0000006" value="1"/>
    476. 

  476.       <parameter id="alphat" name="alphat" metaid="metaid_0000007" value="0"/>
    477. 

  477.       <parameter id="betat" name="betat" metaid="metaid_0000008" value="0"/>
    478. 

  478.       <parameter id="alphas" name="alphas" metaid="metaid_0000009" value="2"/>
    479. 

  479.       <parameter id="betas" name="betas" metaid="metaid_0000010" value="20"/>
    480. 

  480.       <parameter id="alphae" name="alphae" metaid="metaid_0000011" value="10"/>
    481. 

  481.       <parameter id="betae" name="betae" metaid="metaid_0000012" value="360"/>
    482. 

  482.       <parameter id="k3" name="k3" metaid="metaid_0000013" value="1"/>
    483. 

  483.       <parameter id="k4" name="k4" metaid="metaid_0000014" value="1"/>
    484. 

  484.       <parameter id="k5" name="k5" metaid="metaid_0000015" value="1"/>
    485. 

  485.       <parameter id="k6" name="k6" metaid="metaid_0000016" value="1"/>
    486. 

  486.       <parameter id="k9" name="k9" metaid="metaid_0000017" value="1"/>
    487. 

  487.       <parameter id="k10" name="k10" metaid="metaid_0000018" value="1"/>
    488. 

  488.       <parameter id="k11" name="k11" metaid="metaid_0000019" value="1"/>
    489. 

  489.       <parameter id="k12" name="k12" metaid="metaid_0000020" value="1"/>
    490. 

  490.       <parameter id="k13" name="k13" metaid="metaid_0000021" value="1"/>
    491. 

  491.       <parameter id="k17" name="k17" metaid="metaid_0000022" value="1"/>
    492. 

  492.       <parameter id="k19" name="k19" metaid="metaid_0000023" value="1"/>
    493. 

  493.       <parameter id="k20" name="k20" metaid="metaid_0000024" value="1"/>
    494. 

  494.       <parameter id="k21" name="k21" metaid="metaid_0000025" value="1"/>
    495. 

  495.       <parameter id="k22" name="k22" metaid="metaid_0000026" value="1"/>
    496. 

  496.       <parameter id="k23" name="k23" metaid="metaid_0000027" value="1"/>
    497. 

  497.       <parameter id="k25" name="k25" metaid="metaid_0000028" value="1"/>
    498. 

  498.       <parameter id="k27" name="k27" metaid="metaid_0000029" value="1"/>
    499. 

  499.       <parameter id="k31" name="k31" metaid="metaid_0000030" value="1"/>
    500. 

  500.       <parameter id="k32" name="k32" metaid="metaid_0000031" value="1"/>
    501. 

  501.       <parameter id="k33" name="k33" metaid="metaid_0000032" value="1"/>
    502. 

  502.       <parameter id="k34" name="k34" metaid="metaid_0000033" value="1"/>
    503. 

  503.       <parameter id="k8" name="k8" metaid="metaid_0000034" value="0.1"/>
    504. 

  504.       <parameter id="k14" name="k14" metaid="metaid_0000035" value="0.1"/>
    505. 

  505.       <parameter id="k15" name="k15" metaid="metaid_0000036" value="0.1"/>
    506. 

  506.       <parameter id="k16" name="k16" metaid="metaid_0000037" value="0.1"/>
    507. 

  507.       <parameter id="k26" name="k26" metaid="metaid_0000038" value="0.1"/>
    508. 

  508.       <parameter id="k30" name="k30" metaid="metaid_0000039" value="0.1"/>
    509. 

  509.       <parameter id="k7" name="k7" metaid="metaid_0000040" value="10"/>
    510. 

  510.       <parameter id="k18" name="k18" metaid="metaid_0000041" value="10"/>
    511. 

  511.       <parameter id="k1" name="k1" metaid="metaid_0000042" value="0.01"/>
    512. 

  512.       <parameter id="k2" name="k2" metaid="metaid_0000043" value="0.01"/>
    513. 

  513.       <parameter id="k24" name="k24" metaid="metaid_0000044" value="0.01"/>
    514. 

  514.       <parameter id="k28" name="k28" metaid="metaid_0000045" value="0.01"/>
    515. 

  515.       <parameter id="k29" name="k29" metaid="metaid_0000046" value="0.01"/>
    516. 

  516.       <parameter id="alphastim" name="alphastim" metaid="metaid_0000047" value="1"/>
    517. 

  517.       <parameter id="betastim" name="betastim" metaid="metaid_0000048" value="1"/>
    518. 

  518.     </listOfParameters>
    519. 

  519.     <listOfRules>
    520. 

  520.       <assignmentRule metaid="metaid_0000076" variable="alpha">
    521. 

  521.         <math xmlns="http://www.w3.org/1998/Math/MathML">        
    522. 

  522.           <apply>
    523. 

  523.             <times/>
    524. 

  524.             <ci> alphastim </ci>
    525. 

  525.             <piecewise>
    526. 

  526.               <piece>
    527. 

  527.                 <apply>
    528. 

  528.                   <times/>
    529. 

  529.                   <ci> alphaA </ci>
    530. 

  530.                   <apply>
    531. 

  531.                     <minus/>
    532. 

  532.                     <cn type="integer"> 1 </cn>
    533. 

  533.                     <apply>
    534. 

  534.                       <exp/>
    535. 

  535.                       <apply>
    536. 

  536.                         <divide/>
    537. 

  537.                         <apply>
    538. 

  538.                           <minus/>
    539. 

  539.                           <apply>
    540. 

  540.                             <minus/>
    541. 

  541.                             <csymbol encoding="text" definitionURL="http://www.sbml.org/sbml/symbols/time"> time </csymbol>
    542. 

  542.                             <ci> alphat </ci>
    543. 

  543.                           </apply>
    544. 

  544.                         </apply>
    545. 

  545.                         <ci> alphas </ci>
    546. 

  546.                       </apply>
    547. 

  547.                     </apply>
    548. 

  548.                   </apply>
    549. 

  549.                 </apply>
    550. 

  550.                 <apply>
    551. 

  551.                   <and/>
    552. 

  552.                   <apply>
    553. 

  553.                     <geq/>
    554. 

  554.                     <csymbol encoding="text" definitionURL="http://www.sbml.org/sbml/symbols/time"> time </csymbol>
    555. 

  555.                     <ci> alphat </ci>
    556. 

  556.                   </apply>
    557. 

  557.                   <apply>
    558. 

  558.                     <leq/>
    559. 

  559.                     <csymbol encoding="text" definitionURL="http://www.sbml.org/sbml/symbols/time"> time </csymbol>
    560. 

  560.                     <ci> alphae </ci>
    561. 

  561.                   </apply>
    562. 

  562.                 </apply>
    563. 

  563.               </piece>
    564. 

  564.               <otherwise>
    565. 

  565.                 <piecewise>
    566. 

  566.                   <piece>
    567. 

  567.                     <apply>
    568. 

  568.                       <times/>
    569. 

  569.                       <ci> alphaA </ci>
    570. 

  570.                       <apply>
    571. 

  571.                         <exp/>
    572. 

  572.                         <apply>
    573. 

  573.                           <divide/>
    574. 

  574.                           <apply>
    575. 

  575.                             <minus/>
    576. 

  576.                             <apply>
    577. 

  577.                               <minus/>
    578. 

  578.                               <csymbol encoding="text" definitionURL="http://www.sbml.org/sbml/symbols/time"> time </csymbol>
    579. 

  579.                               <ci> alphat </ci>
    580. 

  580.                             </apply>
    581. 

  581.                           </apply>
    582. 

  582.                           <ci> alphas </ci>
    583. 

  583.                         </apply>
    584. 

  584.                       </apply>
    585. 

  585.                     </apply>
    586. 

  586.                     <apply>
    587. 

  587.                       <geq/>
    588. 

  588.                       <csymbol encoding="text" definitionURL="http://www.sbml.org/sbml/symbols/time"> time </csymbol>
    589. 

  589.                       <ci> alphae </ci>
    590. 

  590.                     </apply>
    591. 

  591.                   </piece>
    592. 

  592.                   <otherwise>
    593. 

  593.                     <cn type="integer"> 0 </cn>
    594. 

  594.                   </otherwise>
    595. 

  595.                 </piecewise>
    596. 

  596.               </otherwise>
    597. 

  597.             </piecewise>
    598. 

  598.           </apply>
    599. 

  599.         </math>
    600. 

  600.       </assignmentRule>
    601. 

  601.       <assignmentRule metaid="metaid_0000077" variable="beta">
    602. 

  602.         <math xmlns="http://www.w3.org/1998/Math/MathML">        
    603. 

  603.           <apply>
    604. 

  604.             <times/>
    605. 

  605.             <ci> betastim </ci>
    606. 

  606.             <ci> betaA </ci>
    607. 

  607.             <piecewise>
    608. 

  608.               <piece>
    609. 

  609.                 <apply>
    610. 

  610.                   <minus/>
    611. 

  611.                   <cn type="integer"> 1 </cn>
    612. 

  612.                   <apply>
    613. 

  613.                     <exp/>
    614. 

  614.                     <apply>
    615. 

  615.                       <divide/>
    616. 

  616.                       <apply>
    617. 

  617.                         <minus/>
    618. 

  618.                         <apply>
    619. 

  619.                           <minus/>
    620. 

  620.                           <csymbol encoding="text" definitionURL="http://www.sbml.org/sbml/symbols/time"> time </csymbol>
    621. 

  621.                           <ci> betat </ci>
    622. 

  622.                         </apply>
    623. 

  623.                       </apply>
    624. 

  624.                       <ci> betas </ci>
    625. 

  625.                     </apply>
    626. 

  626.                   </apply>
    627. 

  627.                 </apply>
    628. 

  628.                 <apply>
    629. 

  629.                   <and/>
    630. 

  630.                   <apply>
    631. 

  631.                     <geq/>
    632. 

  632.                     <csymbol encoding="text" definitionURL="http://www.sbml.org/sbml/symbols/time"> time </csymbol>
    633. 

  633.                     <ci> betat </ci>
    634. 

  634.                   </apply>
    635. 

  635.                   <apply>
    636. 

  636.                     <leq/>
    637. 

  637.                     <csymbol encoding="text" definitionURL="http://www.sbml.org/sbml/symbols/time"> time </csymbol>
    638. 

  638.                     <ci> betae </ci>
    639. 

  639.                   </apply>
    640. 

  640.                 </apply>
    641. 

  641.               </piece>
    642. 

  642.               <otherwise>
    643. 

  643.                 <piecewise>
    644. 

  644.                   <piece>
    645. 

  645.                     <apply>
    646. 

  646.                       <exp/>
    647. 

  647.                       <apply>
    648. 

  648.                         <divide/>
    649. 

  649.                         <apply>
    650. 

  650.                           <minus/>
    651. 

  651.                           <apply>
    652. 

  652.                             <minus/>
    653. 

  653.                             <csymbol encoding="text" definitionURL="http://www.sbml.org/sbml/symbols/time"> time </csymbol>
    654. 

  654.                             <ci> betae </ci>
    655. 

  655.                           </apply>
    656. 

  656.                         </apply>
    657. 

  657.                         <ci> betas </ci>
    658. 

  658.                       </apply>
    659. 

  659.                     </apply>
    660. 

  660.                     <apply>
    661. 

  661.                       <gt/>
    662. 

  662.                       <csymbol encoding="text" definitionURL="http://www.sbml.org/sbml/symbols/time"> time </csymbol>
    663. 

  663.                       <ci> betae </ci>
    664. 

  664.                     </apply>
    665. 

  665.                   </piece>
    666. 

  666.                   <otherwise>
    667. 

  667.                     <cn type="integer"> 0 </cn>
    668. 

  668.                   </otherwise>
    669. 

  669.                 </piecewise>
    670. 

  670.               </otherwise>
    671. 

  671.             </piecewise>
    672. 

  672.           </apply>
    673. 

  673.         </math>
    674. 

  674.       </assignmentRule>
    675. 

  675.     </listOfRules>
    676. 

  676.     <listOfReactions>
    677. 

  677.       <reaction id="v1" name="v1" metaid="metaid_0000078" sboTerm="SBO:0000177">
    678. 

  678.         <annotation>
    679. 

  679.           <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
    680. 

  680.             <rdf:Description rdf:about="#metaid_0000078">
    681. 

  681.               <bqbiol:isVersionOf>
    682. 

  682.                 <rdf:Bag>
    683. 

  683.                   <rdf:li rdf:resource="http://identifiers.org/obo.go/GO:0006461"/>
    684. 

  684.                 </rdf:Bag>
    685. 

  685.               </bqbiol:isVersionOf>
    686. 

  686.             </rdf:Description>
    687. 

  687.           </rdf:RDF>
    688. 

  688.         </annotation>
    689. 

  689.               <listOfReactants>
    690. 

  690.           <speciesReference species="Ste5" metaid="_650532"/>
    691. 

  691.           <speciesReference species="Ste11" metaid="_650544"/>
    692. 

  692.         </listOfReactants>
    693. 

  693.         <listOfProducts>
    694. 

  694.           <speciesReference species="Ste5Ste11" metaid="_650556"/>
    695. 

  695.         </listOfProducts>
    696. 

  696.         <kineticLaw metaid="_650568">
    697. 

  697.           <math xmlns="http://www.w3.org/1998/Math/MathML">          
    698. 

  698.             <apply>
    699. 

  699.               <times/>
    700. 

  700.               <ci> compartment </ci>
    701. 

  701.               <ci> k1 </ci>
    702. 

  702.               <ci> Ste5 </ci>
    703. 

  703.               <ci> Ste11 </ci>
    704. 

  704.             </apply>
    705. 

  705.           </math>
    706. 

  706.         </kineticLaw>
    707. 

  707.       </reaction>
    708. 

  708.       <reaction id="v2" name="v2" metaid="metaid_0000079" sboTerm="SBO:0000177">
    709. 

  709.         <annotation>
    710. 

  710.           <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
    711. 

  711.             <rdf:Description rdf:about="#metaid_0000079">
    712. 

  712.               <bqbiol:isVersionOf>
    713. 

  713.                 <rdf:Bag>
    714. 

  714.                   <rdf:li rdf:resource="http://identifiers.org/obo.go/GO:0006461"/>
    715. 

  715.                 </rdf:Bag>
    716. 

  716.               </bqbiol:isVersionOf>
    717. 

  717.             </rdf:Description>
    718. 

  718.           </rdf:RDF>
    719. 

  719.         </annotation>
    720. 

  720.               <listOfReactants>
    721. 

  721.           <speciesReference species="Ste5Ste11" metaid="_650580"/>
    722. 

  722.           <speciesReference species="Gbg" metaid="_650592"/>
    723. 

  723.         </listOfReactants>
    724. 

  724.         <listOfProducts>
    725. 

  725.           <speciesReference species="Ste5Ste11Gbg" metaid="_650605"/>
    726. 

  726.         </listOfProducts>
    727. 

  727.         <kineticLaw metaid="_650617">
    728. 

  728.           <math xmlns="http://www.w3.org/1998/Math/MathML">          
    729. 

  729.             <apply>
    730. 

  730.               <times/>
    731. 

  731.               <ci> compartment </ci>
    732. 

  732.               <ci> k2 </ci>
    733. 

  733.               <ci> Ste5Ste11 </ci>
    734. 

  734.               <ci> Gbg </ci>
    735. 

  735.               <ci> alpha </ci>
    736. 

  736.             </apply>
    737. 

  737.           </math>
    738. 

  738.         </kineticLaw>
    739. 

  739.       </reaction>
    740. 

  740.       <reaction id="v3" name="v3" metaid="metaid_0000080" sboTerm="SBO:0000177">
    741. 

  741.         <annotation>
    742. 

  742.           <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
    743. 

  743.             <rdf:Description rdf:about="#metaid_0000080">
    744. 

  744.               <bqbiol:isVersionOf>
    745. 

  745.                 <rdf:Bag>
    746. 

  746.                   <rdf:li rdf:resource="http://identifiers.org/obo.go/GO:0006461"/>
    747. 

  747.                 </rdf:Bag>
    748. 

  748.               </bqbiol:isVersionOf>
    749. 

  749.             </rdf:Description>
    750. 

  750.           </rdf:RDF>
    751. 

  751.         </annotation>
    752. 

  752.               <listOfReactants>
    753. 

  753.           <speciesReference species="Ste5Ste11Gbg" metaid="_650629"/>
    754. 

  754.           <speciesReference species="Fus3" metaid="_650641"/>
    755. 

  755.         </listOfReactants>
    756. 

  756.         <listOfProducts>
    757. 

  757.           <speciesReference species="Ste5Ste11GbgFus3" metaid="_650653"/>
    758. 

  758.         </listOfProducts>
    759. 

  759.         <kineticLaw metaid="_650665">
    760. 

  760.           <math xmlns="http://www.w3.org/1998/Math/MathML">          
    761. 

  761.             <apply>
    762. 

  762.               <times/>
    763. 

  763.               <ci> compartment </ci>
    764. 

  764.               <ci> k3 </ci>
    765. 

  765.               <ci> Ste5Ste11Gbg </ci>
    766. 

  766.               <ci> Fus3 </ci>
    767. 

  767.             </apply>
    768. 

  768.           </math>
    769. 

  769.         </kineticLaw>
    770. 

  770.       </reaction>
    771. 

  771.       <reaction id="v4" name="v4" metaid="metaid_0000081" sboTerm="SBO:0000216">
    772. 

  772.         <annotation>
    773. 

  773.           <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
    774. 

  774.             <rdf:Description rdf:about="#metaid_0000081">
    775. 

  775.               <bqbiol:isVersionOf>
    776. 

  776.                 <rdf:Bag>
    777. 

  777.                   <rdf:li rdf:resource="http://identifiers.org/obo.go/GO:0016310"/>
    778. 

  778.                 </rdf:Bag>
    779. 

  779.               </bqbiol:isVersionOf>
    780. 

  780.             </rdf:Description>
    781. 

  781.           </rdf:RDF>
    782. 

  782.         </annotation>
    783. 

  783.               <listOfReactants>
    784. 

  784.           <speciesReference species="Ste5Ste11GbgFus3" metaid="_650677"/>
    785. 

  785.         </listOfReactants>
    786. 

  786.         <listOfProducts>
    787. 

  787.           <speciesReference species="Ste5Ste11GbgFus3P" metaid="_650689"/>
    788. 

  788.         </listOfProducts>
    789. 

  789.         <kineticLaw metaid="_650701">
    790. 

  790.           <math xmlns="http://www.w3.org/1998/Math/MathML">          
    791. 

  791.             <apply>
    792. 

  792.               <times/>
    793. 

  793.               <ci> compartment </ci>
    794. 

  794.               <ci> k4 </ci>
    795. 

  795.               <ci> Ste5Ste11GbgFus3 </ci>
    796. 

  796.             </apply>
    797. 

  797.           </math>
    798. 

  798.         </kineticLaw>
    799. 

  799.       </reaction>
    800. 

  800.       <reaction id="v5" name="v5" metaid="metaid_0000082" sboTerm="SBO:0000216">
    801. 

  801.         <annotation>
    802. 

  802.           <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
    803. 

  803.             <rdf:Description rdf:about="#metaid_0000082">
    804. 

  804.               <bqbiol:isVersionOf>
    805. 

  805.                 <rdf:Bag>
    806. 

  806.                   <rdf:li rdf:resource="http://identifiers.org/obo.go/GO:0016310"/>
    807. 

  807.                   <rdf:li rdf:resource="http://identifiers.org/obo.go/GO:0043241"/>
    808. 

  808.                 </rdf:Bag>
    809. 

  809.               </bqbiol:isVersionOf>
    810. 

  810.             </rdf:Description>
    811. 

  811.           </rdf:RDF>
    812. 

  812.         </annotation>
    813. 

  813.               <listOfReactants>
    814. 

  814.           <speciesReference species="Ste5Ste11GbgFus3P" metaid="_650713"/>
    815. 

  815.         </listOfReactants>
    816. 

  816.         <listOfProducts>
    817. 

  817.           <speciesReference species="Fus3PP" metaid="_650725"/>
    818. 

  818.           <speciesReference species="Ste5Ste11GbgP" metaid="_650737"/>
    819. 

  819.         </listOfProducts>
    820. 

  820.         <kineticLaw metaid="_650749">
    821. 

  821.           <math xmlns="http://www.w3.org/1998/Math/MathML">          
    822. 

  822.             <apply>
    823. 

  823.               <times/>
    824. 

  824.               <ci> compartment </ci>
    825. 

  825.               <ci> k5 </ci>
    826. 

  826.               <ci> Ste5Ste11GbgFus3P </ci>
    827. 

  827.             </apply>
    828. 

  828.           </math>
    829. 

  829.         </kineticLaw>
    830. 

  830.       </reaction>
    831. 

  831.       <reaction id="v6" name="v6" metaid="metaid_0000083" sboTerm="SBO:0000177">
    832. 

  832.         <annotation>
    833. 

  833.           <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
    834. 

  834.             <rdf:Description rdf:about="#metaid_0000083">
    835. 

  835.               <bqbiol:isVersionOf>
    836. 

  836.                 <rdf:Bag>
    837. 

  837.                   <rdf:li rdf:resource="http://identifiers.org/obo.go/GO:0006461"/>
    838. 

  838.                 </rdf:Bag>
    839. 

  839.               </bqbiol:isVersionOf>
    840. 

  840.             </rdf:Description>
    841. 

  841.           </rdf:RDF>
    842. 

  842.         </annotation>
    843. 

  843.               <listOfReactants>
    844. 

  844.           <speciesReference species="Fus3" metaid="_650761"/>
    845. 

  845.           <speciesReference species="Ste5Ste11GbgP" metaid="_650773"/>
    846. 

  846.         </listOfReactants>
    847. 

  847.         <listOfProducts>
    848. 

  848.           <speciesReference species="Ste5Ste11GbgFus3P" metaid="_650785"/>
    849. 

  849.         </listOfProducts>
    850. 

  850.         <kineticLaw metaid="_650797">
    851. 

  851.           <math xmlns="http://www.w3.org/1998/Math/MathML">          
    852. 

  852.             <apply>
    853. 

  853.               <times/>
    854. 

  854.               <ci> compartment </ci>
    855. 

  855.               <ci> k6 </ci>
    856. 

  856.               <ci> Fus3 </ci>
    857. 

  857.               <ci> Ste5Ste11GbgP </ci>
    858. 

  858.             </apply>
    859. 

  859.           </math>
    860. 

  860.         </kineticLaw>
    861. 

  861.       </reaction>
    862. 

  862.       <reaction id="v7" name="v7" metaid="metaid_0000084" sboTerm="SBO:0000180">
    863. 

  863.         <annotation>
    864. 

  864.           <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
    865. 

  865.             <rdf:Description rdf:about="#metaid_0000084">
    866. 

  866.               <bqbiol:isVersionOf>
    867. 

  867.                 <rdf:Bag>
    868. 

  868.                   <rdf:li rdf:resource="http://identifiers.org/obo.go/GO:0043241"/>
    869. 

  869.                 </rdf:Bag>
    870. 

  870.               </bqbiol:isVersionOf>
    871. 

  871.             </rdf:Description>
    872. 

  872.           </rdf:RDF>
    873. 

  873.         </annotation>
    874. 

  874.               <listOfReactants>
    875. 

  875.           <speciesReference species="Ste5" metaid="_650810"/>
    876. 

  876.           <speciesReference species="Ste5Ste11GbgP" metaid="_650823"/>
    877. 

  877.         </listOfReactants>
    878. 

  878.         <listOfProducts>
    879. 

  879.           <speciesReference species="Gbg" metaid="_650835"/>
    880. 

  880.           <speciesReference species="Ste11Ubi" metaid="_650847"/>
    881. 

  881.         </listOfProducts>
    882. 

  882.         <kineticLaw metaid="_650859">
    883. 

  883.           <math xmlns="http://www.w3.org/1998/Math/MathML">          
    884. 

  884.             <apply>
    885. 

  885.               <times/>
    886. 

  886.               <ci> compartment </ci>
    887. 

  887.               <ci> k7 </ci>
    888. 

  888.               <ci> Ste5Ste11GbgP </ci>
    889. 

  889.             </apply>
    890. 

  890.           </math>
    891. 

  891.         </kineticLaw>
    892. 

  892.       </reaction>
    893. 

  893.       <reaction id="v8" name="v8" metaid="metaid_0000085" sboTerm="SBO:0000179">
    894. 

  894.         <annotation>
    895. 

  895.           <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
    896. 

  896.             <rdf:Description rdf:about="#metaid_0000085">
    897. 

  897.               <bqbiol:isVersionOf>
    898. 

  898.                 <rdf:Bag>
    899. 

  899.                   <rdf:li rdf:resource="http://identifiers.org/obo.go/GO:0030163"/>
    900. 

  900.                 </rdf:Bag>
    901. 

  901.               </bqbiol:isVersionOf>
    902. 

  902.             </rdf:Description>
    903. 

  903.           </rdf:RDF>
    904. 

  904.         </annotation>
    905. 

  905.               <listOfReactants>
    906. 

  906.           <speciesReference species="Ste11Ubi" metaid="_650871"/>
    907. 

  907.         </listOfReactants>
    908. 

  908.         <listOfProducts>
    909. 

  909.           <speciesReference species="p" metaid="_650883"/>
    910. 

  910.         </listOfProducts>
    911. 

  911.         <kineticLaw metaid="_650895">
    912. 

  912.           <math xmlns="http://www.w3.org/1998/Math/MathML">          
    913. 

  913.             <apply>
    914. 

  914.               <times/>
    915. 

  915.               <ci> compartment </ci>
    916. 

  916.               <ci> k8 </ci>
    917. 

  917.               <ci> Ste11Ubi </ci>
    918. 

  918.             </apply>
    919. 

  919.           </math>
    920. 

  920.         </kineticLaw>
    921. 

  921.       </reaction>
    922. 

  922.       <reaction id="v9" name="v9" metaid="metaid_0000086" sboTerm="SBO:0000177">
    923. 

  923.         <annotation>
    924. 

  924.           <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
    925. 

  925.             <rdf:Description rdf:about="#metaid_0000086">
    926. 

  926.               <bqbiol:isVersionOf>
    927. 

  927.                 <rdf:Bag>
    928. 

  928.                   <rdf:li rdf:resource="http://identifiers.org/obo.go/GO:0006461"/>
    929. 

  929.                 </rdf:Bag>
    930. 

  930.               </bqbiol:isVersionOf>
    931. 

  931.             </rdf:Description>
    932. 

  932.           </rdf:RDF>
    933. 

  933.         </annotation>
    934. 

  934.               <listOfReactants>
    935. 

  935.           <speciesReference species="Ste5Ste11Gbg" metaid="_650907"/>
    936. 

  936.           <speciesReference species="Kss1" metaid="_650920"/>
    937. 

  937.         </listOfReactants>
    938. 

  938.         <listOfProducts>
    939. 

  939.           <speciesReference species="Ste5Ste11GbgKss1" metaid="_650932"/>
    940. 

  940.         </listOfProducts>
    941. 

  941.         <kineticLaw metaid="_650944">
    942. 

  942.           <math xmlns="http://www.w3.org/1998/Math/MathML">          
    943. 

  943.             <apply>
    944. 

  944.               <times/>
    945. 

  945.               <ci> compartment </ci>
    946. 

  946.               <ci> k9 </ci>
    947. 

  947.               <ci> Ste5Ste11Gbg </ci>
    948. 

  948.               <ci> Kss1 </ci>
    949. 

  949.             </apply>
    950. 

  950.           </math>
    951. 

  951.         </kineticLaw>
    952. 

  952.       </reaction>
    953. 

  953.       <reaction id="v10" name="v10" metaid="metaid_0000087" sboTerm="SBO:0000216">
    954. 

  954.         <annotation>
    955. 

  955.           <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
    956. 

  956.             <rdf:Description rdf:about="#metaid_0000087">
    957. 

  957.               <bqbiol:isVersionOf>
    958. 

  958.                 <rdf:Bag>
    959. 

  959.                   <rdf:li rdf:resource="http://identifiers.org/obo.go/GO:0016310"/>
    960. 

  960.                 </rdf:Bag>
    961. 

  961.               </bqbiol:isVersionOf>
    962. 

  962.             </rdf:Description>
    963. 

  963.           </rdf:RDF>
    964. 

  964.         </annotation>
    965. 

  965.               <listOfReactants>
    966. 

  966.           <speciesReference species="Ste5Ste11GbgKss1" metaid="_650956"/>
    967. 

  967.         </listOfReactants>
    968. 

  968.         <listOfProducts>
    969. 

  969.           <speciesReference species="Ste5Ste11GbgKss1P" metaid="_650968"/>
    970. 

  970.         </listOfProducts>
    971. 

  971.         <kineticLaw metaid="_650980">
    972. 

  972.           <math xmlns="http://www.w3.org/1998/Math/MathML">          
    973. 

  973.             <apply>
    974. 

  974.               <times/>
    975. 

  975.               <ci> compartment </ci>
    976. 

  976.               <ci> k10 </ci>
    977. 

  977.               <ci> Ste5Ste11GbgKss1 </ci>
    978. 

  978.             </apply>
    979. 

  979.           </math>
    980. 

  980.         </kineticLaw>
    981. 

  981.       </reaction>
    982. 

  982.       <reaction id="v11" name="v11" metaid="metaid_0000088" sboTerm="SBO:0000216">
    983. 

  983.         <annotation>
    984. 

  984.           <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
    985. 

  985.             <rdf:Description rdf:about="#metaid_0000088">
    986. 

  986.               <bqbiol:isVersionOf>
    987. 

  987.                 <rdf:Bag>
    988. 

  988.                   <rdf:li rdf:resource="http://identifiers.org/obo.go/GO:0016310"/>
    989. 

  989.                   <rdf:li rdf:resource="http://identifiers.org/obo.go/GO:0043241"/>
    990. 

  990.                 </rdf:Bag>
    991. 

  991.               </bqbiol:isVersionOf>
    992. 

  992.             </rdf:Description>
    993. 

  993.           </rdf:RDF>
    994. 

  994.         </annotation>
    995. 

  995.               <listOfReactants>
    996. 

  996.           <speciesReference species="Ste5Ste11GbgKss1P" metaid="_650992"/>
    997. 

  997.         </listOfReactants>
    998. 

  998.         <listOfProducts>
    999. 

  999.           <speciesReference species="Ste5Ste11GbgP" metaid="_651004"/>
    1000. 

  1000.           <speciesReference species="Kss1PP" metaid="_651016"/>
    1001. 

  1001.         </listOfProducts>
    1002. 

  1002.         <kineticLaw metaid="_651028">
    1003. 

  1003.           <math xmlns="http://www.w3.org/1998/Math/MathML">          
    1004. 

  1004.             <apply>
    1005. 

  1005.               <times/>
    1006. 

  1006.               <ci> compartment </ci>
    1007. 

  1007.               <ci> k11 </ci>
    1008. 

  1008.               <ci> Ste5Ste11GbgKss1P </ci>
    1009. 

  1009.             </apply>
    1010. 

  1010.           </math>
    1011. 

  1011.         </kineticLaw>
    1012. 

  1012.       </reaction>
    1013. 

  1013.       <reaction id="v12" name="v12" metaid="metaid_0000089" sboTerm="SBO:0000177">
    1014. 

  1014.         <annotation>
    1015. 

  1015.           <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
    1016. 

  1016.             <rdf:Description rdf:about="#metaid_0000089">
    1017. 

  1017.               <bqbiol:isVersionOf>
    1018. 

  1018.                 <rdf:Bag>
    1019. 

  1019.                   <rdf:li rdf:resource="http://identifiers.org/obo.go/GO:0006461"/>
    1020. 

  1020.                 </rdf:Bag>
    1021. 

  1021.               </bqbiol:isVersionOf>
    1022. 

  1022.             </rdf:Description>
    1023. 

  1023.           </rdf:RDF>
    1024. 

  1024.         </annotation>
    1025. 

  1025.               <listOfReactants>
    1026. 

  1026.           <speciesReference species="Ste5Ste11GbgP" metaid="_651040"/>
    1027. 

  1027.           <speciesReference species="Kss1" metaid="_651052"/>
    1028. 

  1028.         </listOfReactants>
    1029. 

  1029.         <listOfProducts>
    1030. 

  1030.           <speciesReference species="Ste5Ste11GbgKss1P" metaid="_651064"/>
    1031. 

  1031.         </listOfProducts>
    1032. 

  1032.         <kineticLaw metaid="_651076">
    1033. 

  1033.           <math xmlns="http://www.w3.org/1998/Math/MathML">          
    1034. 

  1034.             <apply>
    1035. 

  1035.               <times/>
    1036. 

  1036.               <ci> compartment </ci>
    1037. 

  1037.               <ci> k12 </ci>
    1038. 

  1038.               <ci> Ste5Ste11GbgP </ci>
    1039. 

  1039.               <ci> Kss1 </ci>
    1040. 

  1040.             </apply>
    1041. 

  1041.           </math>
    1042. 

  1042.         </kineticLaw>
    1043. 

  1043.       </reaction>
    1044. 

  1044.       <reaction id="v13" name="v13" metaid="metaid_0000090" sboTerm="SBO:0000216">
    1045. 

  1045.         <annotation>
    1046. 

  1046.           <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
    1047. 

  1047.             <rdf:Description rdf:about="#metaid_0000090">
    1048. 

  1048.               <bqbiol:isVersionOf>
    1049. 

  1049.                 <rdf:Bag>
    1050. 

  1050.                   <rdf:li rdf:resource="http://identifiers.org/obo.go/GO:0016310"/>
    1051. 

  1051.                 </rdf:Bag>
    1052. 

  1052.               </bqbiol:isVersionOf>
    1053. 

  1053.             </rdf:Description>
    1054. 

  1054.           </rdf:RDF>
    1055. 

  1055.         </annotation>
    1056. 

  1056.               <listOfReactants>
    1057. 

  1057.           <speciesReference species="Ste11" metaid="_651088"/>
    1058. 

  1058.         </listOfReactants>
    1059. 

  1059.         <listOfProducts>
    1060. 

  1060.           <speciesReference species="Ste11P" metaid="_651100"/>
    1061. 

  1061.         </listOfProducts>
    1062. 

  1062.         <kineticLaw metaid="_651112">
    1063. 

  1063.           <math xmlns="http://www.w3.org/1998/Math/MathML">          
    1064. 

  1064.             <apply>
    1065. 

  1065.               <times/>
    1066. 

  1066.               <ci> compartment </ci>
    1067. 

  1067.               <ci> k13 </ci>
    1068. 

  1068.               <ci> Ste11 </ci>
    1069. 

  1069.               <ci> beta </ci>
    1070. 

  1070.             </apply>
    1071. 

  1071.           </math>
    1072. 

  1072.         </kineticLaw>
    1073. 

  1073.       </reaction>
    1074. 

  1074.       <reaction id="v14" name="v14" metaid="metaid_0000091" sboTerm="SBO:0000330">
    1075. 

  1075.         <annotation>
    1076. 

  1076.           <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
    1077. 

  1077.             <rdf:Description rdf:about="#metaid_0000091">
    1078. 

  1078.               <bqbiol:isVersionOf>
    1079. 

  1079.                 <rdf:Bag>
    1080. 

  1080.                   <rdf:li rdf:resource="http://identifiers.org/obo.go/GO:0016311"/>
    1081. 

  1081.                 </rdf:Bag>
    1082. 

  1082.               </bqbiol:isVersionOf>
    1083. 

  1083.             </rdf:Description>
    1084. 

  1084.           </rdf:RDF>
    1085. 

  1085.         </annotation>
    1086. 

  1086.               <listOfReactants>
    1087. 

  1087.           <speciesReference species="Ste11P" metaid="_651124"/>
    1088. 

  1088.         </listOfReactants>
    1089. 

  1089.         <listOfProducts>
    1090. 

  1090.           <speciesReference species="Ste11" metaid="_651136"/>
    1091. 

  1091.         </listOfProducts>
    1092. 

  1092.         <kineticLaw metaid="_651148">
    1093. 

  1093.           <math xmlns="http://www.w3.org/1998/Math/MathML">          
    1094. 

  1094.             <apply>
    1095. 

  1095.               <times/>
    1096. 

  1096.               <ci> compartment </ci>
    1097. 

  1097.               <ci> k14 </ci>
    1098. 

  1098.               <ci> Ste11P </ci>
    1099. 

  1099.             </apply>
    1100. 

  1100.           </math>
    1101. 

  1101.         </kineticLaw>
    1102. 

  1102.       </reaction>
    1103. 

  1103.       <reaction id="v15" name="v15" metaid="metaid_0000092" sboTerm="SBO:0000216">
    1104. 

  1104.         <annotation>
    1105. 

  1105.           <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
    1106. 

  1106.             <rdf:Description rdf:about="#metaid_0000092">
    1107. 

  1107.               <bqbiol:isVersionOf>
    1108. 

  1108.                 <rdf:Bag>
    1109. 

  1109.                   <rdf:li rdf:resource="http://identifiers.org/obo.go/GO:0016310"/>
    1110. 

  1110.                 </rdf:Bag>
    1111. 

  1111.               </bqbiol:isVersionOf>
    1112. 

  1112.             </rdf:Description>
    1113. 

  1113.           </rdf:RDF>
    1114. 

  1114.         </annotation>
    1115. 

  1115.               <listOfReactants>
    1116. 

  1116.           <speciesReference species="Kss1" metaid="_651160"/>
    1117. 

  1117.         </listOfReactants>
    1118. 

  1118.         <listOfProducts>
    1119. 

  1119.           <speciesReference species="Kss1PP" metaid="_651172"/>
    1120. 

  1120.         </listOfProducts>
    1121. 

  1121.         <listOfModifiers>
    1122. 

  1122.           <modifierSpeciesReference species="Ste11P" metaid="_651184"/>
    1123. 

  1123.           <modifierSpeciesReference species="Ste11Ubi" metaid="_651196"/>
    1124. 

  1124.         </listOfModifiers>
    1125. 

  1125.         <kineticLaw metaid="_651209">
    1126. 

  1126.           <math xmlns="http://www.w3.org/1998/Math/MathML">          
    1127. 

  1127.             <apply>
    1128. 

  1128.               <times/>
    1129. 

  1129.               <ci> compartment </ci>
    1130. 

  1130.               <apply>
    1131. 

  1131.                 <plus/>
    1132. 

  1132.                 <apply>
    1133. 

  1133.                   <times/>
    1134. 

  1134.                   <ci> k15 </ci>
    1135. 

  1135.                   <ci> Kss1 </ci>
    1136. 

  1136.                   <ci> Ste11P </ci>
    1137. 

  1137.                 </apply>
    1138. 

  1138.                 <apply>
    1139. 

  1139.                   <times/>
    1140. 

  1140.                   <ci> k30 </ci>
    1141. 

  1141.                   <ci> Kss1 </ci>
    1142. 

  1142.                   <ci> Ste11Ubi </ci>
    1143. 

  1143.                 </apply>
    1144. 

  1144.               </apply>
    1145. 

  1145.             </apply>
    1146. 

  1146.           </math>
    1147. 

  1147.         </kineticLaw>
    1148. 

  1148.       </reaction>
    1149. 

  1149.       <reaction id="v16" name="v16" metaid="metaid_0000093" sboTerm="SBO:0000330">
    1150. 

  1150.         <annotation>
    1151. 

  1151.           <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
    1152. 

  1152.             <rdf:Description rdf:about="#metaid_0000093">
    1153. 

  1153.               <bqbiol:isVersionOf>
    1154. 

  1154.                 <rdf:Bag>
    1155. 

  1155.                   <rdf:li rdf:resource="http://identifiers.org/obo.go/GO:0016311"/>
    1156. 

  1156.                 </rdf:Bag>
    1157. 

  1157.               </bqbiol:isVersionOf>
    1158. 

  1158.             </rdf:Description>
    1159. 

  1159.           </rdf:RDF>
    1160. 

  1160.         </annotation>
    1161. 

  1161.               <listOfReactants>
    1162. 

  1162.           <speciesReference species="Kss1PP" metaid="_651221"/>
    1163. 

  1163.         </listOfReactants>
    1164. 

  1164.         <listOfProducts>
    1165. 

  1165.           <speciesReference species="Kss1" metaid="_651233"/>
    1166. 

  1166.         </listOfProducts>
    1167. 

  1167.         <listOfModifiers>
    1168. 

  1168.           <modifierSpeciesReference species="Fus3PP" metaid="_651245"/>
    1169. 

  1169.         </listOfModifiers>
    1170. 

  1170.         <kineticLaw metaid="_651257">
    1171. 

  1171.           <math xmlns="http://www.w3.org/1998/Math/MathML">          
    1172. 

  1172.             <apply>
    1173. 

  1173.               <times/>
    1174. 

  1174.               <ci> compartment </ci>
    1175. 

  1175.               <apply>
    1176. 

  1176.                 <plus/>
    1177. 

  1177.                 <apply>
    1178. 

  1178.                   <times/>
    1179. 

  1179.                   <ci> k16 </ci>
    1180. 

  1180.                   <ci> Kss1PP </ci>
    1181. 

  1181.                 </apply>
    1182. 

  1182.                 <apply>
    1183. 

  1183.                   <times/>
    1184. 

  1184.                   <ci> k28 </ci>
    1185. 

  1185.                   <ci> Kss1PP </ci>
    1186. 

  1186.                   <ci> Fus3PP </ci>
    1187. 

  1187.                 </apply>
    1188. 

  1188.               </apply>
    1189. 

  1189.             </apply>
    1190. 

  1190.           </math>
    1191. 

  1191.         </kineticLaw>
    1192. 

  1192.       </reaction>
    1193. 

  1193.       <reaction id="v17" name="v17" metaid="metaid_0000094" sboTerm="SBO:0000180">
    1194. 

  1194.         <annotation>
    1195. 

  1195.           <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
    1196. 

  1196.             <rdf:Description rdf:about="#metaid_0000094">
    1197. 

  1197.               <bqbiol:isVersionOf>
    1198. 

  1198.                 <rdf:Bag>
    1199. 

  1199.                   <rdf:li rdf:resource="http://identifiers.org/obo.go/GO:0043241"/>
    1200. 

  1200.                 </rdf:Bag>
    1201. 

  1201.               </bqbiol:isVersionOf>
    1202. 

  1202.             </rdf:Description>
    1203. 

  1203.           </rdf:RDF>
    1204. 

  1204.         </annotation>
    1205. 

  1205.               <listOfReactants>
    1206. 

  1206.           <speciesReference species="Ste12Kss1" metaid="_651269"/>
    1207. 

  1207.         </listOfReactants>
    1208. 

  1208.         <listOfProducts>
    1209. 

  1209.           <speciesReference species="Kss1" metaid="_651281" stoichiometry="2"/>
    1210. 

  1210.           <speciesReference species="Ste12" metaid="_651293"/>
    1211. 

  1211.         </listOfProducts>
    1212. 

  1212.         <kineticLaw metaid="_651306">
    1213. 

  1213.           <math xmlns="http://www.w3.org/1998/Math/MathML">          
    1214. 

  1214.             <apply>
    1215. 

  1215.               <times/>
    1216. 

  1216.               <ci> compartment </ci>
    1217. 

  1217.               <ci> k17 </ci>
    1218. 

  1218.               <ci> Ste12Kss1 </ci>
    1219. 

  1219.             </apply>
    1220. 

  1220.           </math>
    1221. 

  1221.         </kineticLaw>
    1222. 

  1222.       </reaction>
    1223. 

  1223.       <reaction id="v18" name="v18" metaid="metaid_0000095" sboTerm="SBO:0000177">
    1224. 

  1224.         <annotation>
    1225. 

  1225.           <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
    1226. 

  1226.             <rdf:Description rdf:about="#metaid_0000095">
    1227. 

  1227.               <bqbiol:isVersionOf>
    1228. 

  1228.                 <rdf:Bag>
    1229. 

  1229.                   <rdf:li rdf:resource="http://identifiers.org/obo.go/GO:0006461"/>
    1230. 

  1230.                 </rdf:Bag>
    1231. 

  1231.               </bqbiol:isVersionOf>
    1232. 

  1232.             </rdf:Description>
    1233. 

  1233.           </rdf:RDF>
    1234. 

  1234.         </annotation>
    1235. 

  1235.               <listOfReactants>
    1236. 

  1236.           <speciesReference species="Kss1" metaid="_651319" stoichiometry="2"/>
    1237. 

  1237.           <speciesReference species="Ste12" metaid="_651331"/>
    1238. 

  1238.         </listOfReactants>
    1239. 

  1239.         <listOfProducts>
    1240. 

  1240.           <speciesReference species="Ste12Kss1" metaid="_651343"/>
    1241. 

  1241.         </listOfProducts>
    1242. 

  1242.         <kineticLaw metaid="_651355">
    1243. 

  1243.           <math xmlns="http://www.w3.org/1998/Math/MathML">          
    1244. 

  1244.             <apply>
    1245. 

  1245.               <times/>
    1246. 

  1246.               <ci> compartment </ci>
    1247. 

  1247.               <ci> k18 </ci>
    1248. 

  1248.               <ci> Kss1 </ci>
    1249. 

  1249.               <ci> Ste12 </ci>
    1250. 

  1250.             </apply>
    1251. 

  1251.           </math>
    1252. 

  1252.         </kineticLaw>
    1253. 

  1253.       </reaction>
    1254. 

  1254.       <reaction id="v19" name="v19" metaid="metaid_0000096" sboTerm="SBO:0000216">
    1255. 

  1255.         <annotation>
    1256. 

  1256.           <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
    1257. 

  1257.             <rdf:Description rdf:about="#metaid_0000096">
    1258. 

  1258.               <bqbiol:isVersionOf>
    1259. 

  1259.                 <rdf:Bag>
    1260. 

  1260.                   <rdf:li rdf:resource="http://identifiers.org/obo.go/GO:0016310"/>
    1261. 

  1261.                 </rdf:Bag>
    1262. 

  1262.               </bqbiol:isVersionOf>
    1263. 

  1263.             </rdf:Description>
    1264. 

  1264.           </rdf:RDF>
    1265. 

  1265.         </annotation>
    1266. 

  1266.               <listOfReactants>
    1267. 

  1267.           <speciesReference species="Ste12" metaid="_651367"/>
    1268. 

  1268.         </listOfReactants>
    1269. 

  1269.         <listOfProducts>
    1270. 

  1270.           <speciesReference species="Ste12P" metaid="_651379"/>
    1271. 

  1271.         </listOfProducts>
    1272. 

  1272.         <listOfModifiers>
    1273. 

  1273.           <modifierSpeciesReference species="Fus3PP" metaid="_651391"/>
    1274. 

  1274.           <modifierSpeciesReference species="Kss1PP" metaid="_651403"/>
    1275. 

  1275.         </listOfModifiers>
    1276. 

  1276.         <kineticLaw metaid="_651415">
    1277. 

  1277.           <math xmlns="http://www.w3.org/1998/Math/MathML">          
    1278. 

  1278.             <apply>
    1279. 

  1279.               <times/>
    1280. 

  1280.               <ci> compartment </ci>
    1281. 

  1281.               <apply>
    1282. 

  1282.                 <plus/>
    1283. 

  1283.                 <apply>
    1284. 

  1284.                   <times/>
    1285. 

  1285.                   <ci> k19 </ci>
    1286. 

  1286.                   <ci> Ste12 </ci>
    1287. 

  1287.                   <ci> Fus3PP </ci>
    1288. 

  1288.                 </apply>
    1289. 

  1289.                 <apply>
    1290. 

  1290.                   <times/>
    1291. 

  1291.                   <ci> k29 </ci>
    1292. 

  1292.                   <ci> Ste12 </ci>
    1293. 

  1293.                   <ci> Kss1PP </ci>
    1294. 

  1294.                 </apply>
    1295. 

  1295.               </apply>
    1296. 

  1296.             </apply>
    1297. 

  1297.           </math>
    1298. 

  1298.         </kineticLaw>
    1299. 

  1299.       </reaction>
    1300. 

  1300.       <reaction id="v20" name="v20" metaid="metaid_0000097" sboTerm="SBO:0000205">
    1301. 

  1301.         <annotation>
    1302. 

  1302.           <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
    1303. 

  1303.             <rdf:Description rdf:about="#metaid_0000097">
    1304. 

  1304.               <bqbiol:isVersionOf>
    1305. 

  1305.                 <rdf:Bag>
    1306. 

  1306.                   <rdf:li rdf:resource="http://identifiers.org/obo.go/GO:0010467"/>
    1307. 

  1307.                 </rdf:Bag>
    1308. 

  1308.               </bqbiol:isVersionOf>
    1309. 

  1309.             </rdf:Description>
    1310. 

  1310.           </rdf:RDF>
    1311. 

  1311.         </annotation>
    1312. 

  1312.               <listOfReactants>
    1313. 

  1313.           <speciesReference species="s" metaid="_651427"/>
    1314. 

  1314.         </listOfReactants>
    1315. 

  1315.         <listOfProducts>
    1316. 

  1316.           <speciesReference species="PREP" metaid="_651439"/>
    1317. 

  1317.         </listOfProducts>
    1318. 

  1318.         <listOfModifiers>
    1319. 

  1319.           <modifierSpeciesReference species="Ste12P" metaid="_651452"/>
    1320. 

  1320.         </listOfModifiers>
    1321. 

  1321.         <kineticLaw metaid="_651464">
    1322. 

  1322.           <math xmlns="http://www.w3.org/1998/Math/MathML">          
    1323. 

  1323.             <apply>
    1324. 

  1324.               <times/>
    1325. 

  1325.               <ci> compartment </ci>
    1326. 

  1326.               <ci> k20 </ci>
    1327. 

  1327.               <ci> Ste12P </ci>
    1328. 

  1328.             </apply>
    1329. 

  1329.           </math>
    1330. 

  1330.         </kineticLaw>
    1331. 

  1331.       </reaction>
    1332. 

  1332.       <reaction id="v21" name="v21" metaid="metaid_0000098" sboTerm="SBO:0000180">
    1333. 

  1333.         <annotation>
    1334. 

  1334.           <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
    1335. 

  1335.             <rdf:Description rdf:about="#metaid_0000098">
    1336. 

  1336.               <bqbiol:isVersionOf>
    1337. 

  1337.                 <rdf:Bag>
    1338. 

  1338.                   <rdf:li rdf:resource="http://identifiers.org/obo.go/GO:0043241"/>
    1339. 

  1339.                 </rdf:Bag>
    1340. 

  1340.               </bqbiol:isVersionOf>
    1341. 

  1341.             </rdf:Description>
    1342. 

  1342.           </rdf:RDF>
    1343. 

  1343.         </annotation>
    1344. 

  1344.               <listOfReactants>
    1345. 

  1345.           <speciesReference species="Ste12TeSte5Kss1" metaid="_651476"/>
    1346. 

  1346.         </listOfReactants>
    1347. 

  1347.         <listOfProducts>
    1348. 

  1348.           <speciesReference species="Kss1" metaid="_651488"/>
    1349. 

  1349.           <speciesReference species="Ste12TeSte5" metaid="_651500"/>
    1350. 

  1350.         </listOfProducts>
    1351. 

  1351.         <kineticLaw metaid="_651512">
    1352. 

  1352.           <math xmlns="http://www.w3.org/1998/Math/MathML">          
    1353. 

  1353.             <apply>
    1354. 

  1354.               <times/>
    1355. 

  1355.               <ci> compartment </ci>
    1356. 

  1356.               <ci> k21 </ci>
    1357. 

  1357.               <ci> Ste12TeSte5Kss1 </ci>
    1358. 

  1358.             </apply>
    1359. 

  1359.           </math>
    1360. 

  1360.         </kineticLaw>
    1361. 

  1361.       </reaction>
    1362. 

  1362.       <reaction id="v22" name="v22" metaid="metaid_0000099" sboTerm="SBO:0000177">
    1363. 

  1363.         <annotation>
    1364. 

  1364.           <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
    1365. 

  1365.             <rdf:Description rdf:about="#metaid_0000099">
    1366. 

  1366.               <bqbiol:isVersionOf>
    1367. 

  1367.                 <rdf:Bag>
    1368. 

  1368.                   <rdf:li rdf:resource="http://identifiers.org/obo.go/GO:0006461"/>
    1369. 

  1369.                 </rdf:Bag>
    1370. 

  1370.               </bqbiol:isVersionOf>
    1371. 

  1371.             </rdf:Description>
    1372. 

  1372.           </rdf:RDF>
    1373. 

  1373.         </annotation>
    1374. 

  1374.               <listOfReactants>
    1375. 

  1375.           <speciesReference species="Kss1" metaid="_651524"/>
    1376. 

  1376.           <speciesReference species="Ste12TeSte5" metaid="_651536"/>
    1377. 

  1377.         </listOfReactants>
    1378. 

  1378.         <listOfProducts>
    1379. 

  1379.           <speciesReference species="Ste12TeSte5Kss1" metaid="_651548"/>
    1380. 

  1380.         </listOfProducts>
    1381. 

  1381.         <kineticLaw metaid="_651560">
    1382. 

  1382.           <math xmlns="http://www.w3.org/1998/Math/MathML">          
    1383. 

  1383.             <apply>
    1384. 

  1384.               <times/>
    1385. 

  1385.               <ci> compartment </ci>
    1386. 

  1386.               <ci> k22 </ci>
    1387. 

  1387.               <ci> Kss1 </ci>
    1388. 

  1388.               <ci> Ste12TeSte5 </ci>
    1389. 

  1389.             </apply>
    1390. 

  1390.           </math>
    1391. 

  1391.         </kineticLaw>
    1392. 

  1392.       </reaction>
    1393. 

  1393.       <reaction id="v23" name="v23" metaid="metaid_0000100" sboTerm="SBO:0000216">
    1394. 

  1394.         <annotation>
    1395. 

  1395.           <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
    1396. 

  1396.             <rdf:Description rdf:about="#metaid_0000100">
    1397. 

  1397.               <bqbiol:isVersionOf>
    1398. 

  1398.                 <rdf:Bag>
    1399. 

  1399.                   <rdf:li rdf:resource="http://identifiers.org/obo.go/GO:0016310"/>
    1400. 

  1400.                 </rdf:Bag>
    1401. 

  1401.               </bqbiol:isVersionOf>
    1402. 

  1402.             </rdf:Description>
    1403. 

  1403.           </rdf:RDF>
    1404. 

  1404.         </annotation>
    1405. 

  1405.               <listOfReactants>
    1406. 

  1406.           <speciesReference species="Ste12TeSte5" metaid="_651572"/>
    1407. 

  1407.         </listOfReactants>
    1408. 

  1408.         <listOfProducts>
    1409. 

  1409.           <speciesReference species="Ste12TeSte5P" metaid="_651584"/>
    1410. 

  1410.         </listOfProducts>
    1411. 

  1411.         <listOfModifiers>
    1412. 

  1412.           <modifierSpeciesReference species="Kss1PP" metaid="_651596"/>
    1413. 

  1413.         </listOfModifiers>
    1414. 

  1414.         <kineticLaw metaid="_651608">
    1415. 

  1415.           <math xmlns="http://www.w3.org/1998/Math/MathML">          
    1416. 

  1416.             <apply>
    1417. 

  1417.               <times/>
    1418. 

  1418.               <ci> compartment </ci>
    1419. 

  1419.               <ci> k23 </ci>
    1420. 

  1420.               <ci> Ste12TeSte5 </ci>
    1421. 

  1421.               <ci> Kss1PP </ci>
    1422. 

  1422.             </apply>
    1423. 

  1423.           </math>
    1424. 

  1424.         </kineticLaw>
    1425. 

  1425.       </reaction>
    1426. 

  1426.       <reaction id="v24" name="v24" metaid="metaid_0000101" sboTerm="SBO:0000179">
    1427. 

  1427.         <listOfReactants>
    1428. 

  1428.           <speciesReference species="Ste12TeSte5" metaid="_651620"/>
    1429. 

  1429.         </listOfReactants>
    1430. 

  1430.         <listOfProducts>
    1431. 

  1431.           <speciesReference species="p" metaid="_651632"/>
    1432. 

  1432.         </listOfProducts>
    1433. 

  1433.         <listOfModifiers>
    1434. 

  1434.           <modifierSpeciesReference species="Fus3PP" metaid="_651644"/>
    1435. 

  1435.         </listOfModifiers>
    1436. 

  1436.         <kineticLaw metaid="_651656">
    1437. 

  1437.           <math xmlns="http://www.w3.org/1998/Math/MathML">          
    1438. 

  1438.             <apply>
    1439. 

  1439.               <times/>
    1440. 

  1440.               <ci> compartment </ci>
    1441. 

  1441.               <ci> k24 </ci>
    1442. 

  1442.               <ci> Ste12TeSte5 </ci>
    1443. 

  1443.               <ci> Fus3PP </ci>
    1444. 

  1444.             </apply>
    1445. 

  1445.           </math>
    1446. 

  1446.         </kineticLaw>
    1447. 

  1447.       </reaction>
    1448. 

  1448.       <reaction id="v25" name="v25" metaid="metaid_0000102" sboTerm="SBO:0000205">
    1449. 

  1449.         <annotation>
    1450. 

  1450.           <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
    1451. 

  1451.             <rdf:Description rdf:about="#metaid_0000102">
    1452. 

  1452.               <bqbiol:isVersionOf>
    1453. 

  1453.                 <rdf:Bag>
    1454. 

  1454.                   <rdf:li rdf:resource="http://identifiers.org/obo.go/GO:0010467"/>
    1455. 

  1455.                 </rdf:Bag>
    1456. 

  1456.               </bqbiol:isVersionOf>
    1457. 

  1457.             </rdf:Description>
    1458. 

  1458.           </rdf:RDF>
    1459. 

  1459.         </annotation>
    1460. 

  1460.               <listOfReactants>
    1461. 

  1461.           <speciesReference species="s" metaid="_651668"/>
    1462. 

  1462.         </listOfReactants>
    1463. 

  1463.         <listOfProducts>
    1464. 

  1464.           <speciesReference species="FREP" metaid="_651680"/>
    1465. 

  1465.         </listOfProducts>
    1466. 

  1466.         <listOfModifiers>
    1467. 

  1467.           <modifierSpeciesReference species="Ste12TeSte5P" metaid="_651692"/>
    1468. 

  1468.         </listOfModifiers>
    1469. 

  1469.         <kineticLaw metaid="_651704">
    1470. 

  1470.           <math xmlns="http://www.w3.org/1998/Math/MathML">          
    1471. 

  1471.             <apply>
    1472. 

  1472.               <times/>
    1473. 

  1473.               <ci> compartment </ci>
    1474. 

  1474.               <ci> k25 </ci>
    1475. 

  1475.               <ci> Ste12TeSte5P </ci>
    1476. 

  1476.             </apply>
    1477. 

  1477.           </math>
    1478. 

  1478.         </kineticLaw>
    1479. 

  1479.       </reaction>
    1480. 

  1480.       <reaction id="v26" name="v26" metaid="metaid_0000103" sboTerm="SBO:0000330">
    1481. 

  1481.         <annotation>
    1482. 

  1482.           <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
    1483. 

  1483.             <rdf:Description rdf:about="#metaid_0000103">
    1484. 

  1484.               <bqbiol:isVersionOf>
    1485. 

  1485.                 <rdf:Bag>
    1486. 

  1486.                   <rdf:li rdf:resource="http://identifiers.org/obo.go/GO:0016311"/>
    1487. 

  1487.                 </rdf:Bag>
    1488. 

  1488.               </bqbiol:isVersionOf>
    1489. 

  1489.             </rdf:Description>
    1490. 

  1490.           </rdf:RDF>
    1491. 

  1491.         </annotation>
    1492. 

  1492.               <listOfReactants>
    1493. 

  1493.           <speciesReference species="Fus3PP" metaid="_651716"/>
    1494. 

  1494.         </listOfReactants>
    1495. 

  1495.         <listOfProducts>
    1496. 

  1496.           <speciesReference species="Fus3" metaid="_651728"/>
    1497. 

  1497.         </listOfProducts>
    1498. 

  1498.         <kineticLaw metaid="_651740">
    1499. 

  1499.           <math xmlns="http://www.w3.org/1998/Math/MathML">          
    1500. 

  1500.             <apply>
    1501. 

  1501.               <times/>
    1502. 

  1502.               <ci> compartment </ci>
    1503. 

  1503.               <ci> k26 </ci>
    1504. 

  1504.               <ci> Fus3PP </ci>
    1505. 

  1505.             </apply>
    1506. 

  1506.           </math>
    1507. 

  1507.         </kineticLaw>
    1508. 

  1508.       </reaction>
    1509. 

  1509.       <reaction id="v27" name="v27" metaid="metaid_0000104" sboTerm="SBO:0000180">
    1510. 

  1510.         <annotation>
    1511. 

  1511.           <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
    1512. 

  1512.             <rdf:Description rdf:about="#metaid_0000104">
    1513. 

  1513.               <bqbiol:isVersionOf>
    1514. 

  1514.                 <rdf:Bag>
    1515. 

  1515.                   <rdf:li rdf:resource="http://identifiers.org/obo.go/GO:0043241"/>
    1516. 

  1516.                 </rdf:Bag>
    1517. 

  1517.               </bqbiol:isVersionOf>
    1518. 

  1518.             </rdf:Description>
    1519. 

  1519.           </rdf:RDF>
    1520. 

  1520.         </annotation>
    1521. 

  1521.               <listOfReactants>
    1522. 

  1522.           <speciesReference species="Ste5Ste11" metaid="_651752"/>
    1523. 

  1523.         </listOfReactants>
    1524. 

  1524.         <listOfProducts>
    1525. 

  1525.           <speciesReference species="Ste5" metaid="_651764"/>
    1526. 

  1526.           <speciesReference species="Ste11" metaid="_651776"/>
    1527. 

  1527.         </listOfProducts>
    1528. 

  1528.         <kineticLaw metaid="_651788">
    1529. 

  1529.           <math xmlns="http://www.w3.org/1998/Math/MathML">          
    1530. 

  1530.             <apply>
    1531. 

  1531.               <times/>
    1532. 

  1532.               <ci> compartment </ci>
    1533. 

  1533.               <ci> k27 </ci>
    1534. 

  1534.               <ci> Ste5Ste11 </ci>
    1535. 

  1535.             </apply>
    1536. 

  1536.           </math>
    1537. 

  1537.         </kineticLaw>
    1538. 

  1538.       </reaction>
    1539. 

  1539.       <reaction id="v28" name="v28" metaid="metaid_0000105" sboTerm="SBO:0000330">
    1540. 

  1540.         <annotation>
    1541. 

  1541.           <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
    1542. 

  1542.             <rdf:Description rdf:about="#metaid_0000105">
    1543. 

  1543.               <bqbiol:isVersionOf>
    1544. 

  1544.                 <rdf:Bag>
    1545. 

  1545.                   <rdf:li rdf:resource="http://identifiers.org/obo.go/GO:0016311"/>
    1546. 

  1546.                 </rdf:Bag>
    1547. 

  1547.               </bqbiol:isVersionOf>
    1548. 

  1548.             </rdf:Description>
    1549. 

  1549.           </rdf:RDF>
    1550. 

  1550.         </annotation>
    1551. 

  1551.               <listOfReactants>
    1552. 

  1552.           <speciesReference species="Ste12P" metaid="_651800"/>
    1553. 

  1553.         </listOfReactants>
    1554. 

  1554.         <listOfProducts>
    1555. 

  1555.           <speciesReference species="Ste12" metaid="_651812"/>
    1556. 

  1556.         </listOfProducts>
    1557. 

  1557.         <kineticLaw metaid="_651824">
    1558. 

  1558.           <math xmlns="http://www.w3.org/1998/Math/MathML">          
    1559. 

  1559.             <apply>
    1560. 

  1560.               <times/>
    1561. 

  1561.               <ci> compartment </ci>
    1562. 

  1562.               <ci> k31 </ci>
    1563. 

  1563.               <ci> Ste12P </ci>
    1564. 

  1564.             </apply>
    1565. 

  1565.           </math>
    1566. 

  1566.         </kineticLaw>
    1567. 

  1567.       </reaction>
    1568. 

  1568.       <reaction id="v29" name="v29" metaid="metaid_0000106" sboTerm="SBO:0000179">
    1569. 

  1569.         <annotation>
    1570. 

  1570.           <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
    1571. 

  1571.             <rdf:Description rdf:about="#metaid_0000106">
    1572. 

  1572.               <bqbiol:isVersionOf>
    1573. 

  1573.                 <rdf:Bag>
    1574. 

  1574.                   <rdf:li rdf:resource="http://identifiers.org/obo.go/GO:0030163"/>
    1575. 

  1575.                 </rdf:Bag>
    1576. 

  1576.               </bqbiol:isVersionOf>
    1577. 

  1577.             </rdf:Description>
    1578. 

  1578.           </rdf:RDF>
    1579. 

  1579.         </annotation>
    1580. 

  1580.               <listOfReactants>
    1581. 

  1581.           <speciesReference species="PREP" metaid="_651836"/>
    1582. 

  1582.         </listOfReactants>
    1583. 

  1583.         <listOfProducts>
    1584. 

  1584.           <speciesReference species="p" metaid="_651848"/>
    1585. 

  1585.         </listOfProducts>
    1586. 

  1586.         <kineticLaw metaid="_651860">
    1587. 

  1587.           <math xmlns="http://www.w3.org/1998/Math/MathML">          
    1588. 

  1588.             <apply>
    1589. 

  1589.               <times/>
    1590. 

  1590.               <ci> compartment </ci>
    1591. 

  1591.               <ci> k32 </ci>
    1592. 

  1592.               <ci> PREP </ci>
    1593. 

  1593.             </apply>
    1594. 

  1594.           </math>
    1595. 

  1595.         </kineticLaw>
    1596. 

  1596.       </reaction>
    1597. 

  1597.       <reaction id="v30" name="v30" metaid="metaid_0000107" sboTerm="SBO:0000330">
    1598. 

  1598.         <annotation>
    1599. 

  1599.           <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
    1600. 

  1600.             <rdf:Description rdf:about="#metaid_0000107">
    1601. 

  1601.               <bqbiol:isVersionOf>
    1602. 

  1602.                 <rdf:Bag>
    1603. 

  1603.                   <rdf:li rdf:resource="http://identifiers.org/obo.go/GO:0016311"/>
    1604. 

  1604.                 </rdf:Bag>
    1605. 

  1605.               </bqbiol:isVersionOf>
    1606. 

  1606.             </rdf:Description>
    1607. 

  1607.           </rdf:RDF>
    1608. 

  1608.         </annotation>
    1609. 

  1609.               <listOfReactants>
    1610. 

  1610.           <speciesReference species="Ste12TeSte5P" metaid="_651872"/>
    1611. 

  1611.         </listOfReactants>
    1612. 

  1612.         <listOfProducts>
    1613. 

  1613.           <speciesReference species="Ste12TeSte5" metaid="_651884"/>
    1614. 

  1614.         </listOfProducts>
    1615. 

  1615.         <kineticLaw metaid="_651896">
    1616. 

  1616.           <math xmlns="http://www.w3.org/1998/Math/MathML">          
    1617. 

  1617.             <apply>
    1618. 

  1618.               <times/>
    1619. 

  1619.               <ci> compartment </ci>
    1620. 

  1620.               <ci> k33 </ci>
    1621. 

  1621.               <ci> Ste12TeSte5P </ci>
    1622. 

  1622.             </apply>
    1623. 

  1623.           </math>
    1624. 

  1624.         </kineticLaw>
    1625. 

  1625.       </reaction>
    1626. 

  1626.       <reaction id="v31" name="v31" metaid="metaid_0000108" sboTerm="SBO:0000179">
    1627. 

  1627.         <annotation>
    1628. 

  1628.           <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
    1629. 

  1629.             <rdf:Description rdf:about="#metaid_0000108">
    1630. 

  1630.               <bqbiol:isVersionOf>
    1631. 

  1631.                 <rdf:Bag>
    1632. 

  1632.                   <rdf:li rdf:resource="http://identifiers.org/obo.go/GO:0030163"/>
    1633. 

  1633.                 </rdf:Bag>
    1634. 

  1634.               </bqbiol:isVersionOf>
    1635. 

  1635.             </rdf:Description>
    1636. 

  1636.           </rdf:RDF>
    1637. 

  1637.         </annotation>
    1638. 

  1638.               <listOfReactants>
    1639. 

  1639.           <speciesReference species="FREP" metaid="_651908"/>
    1640. 

  1640.         </listOfReactants>
    1641. 

  1641.         <listOfProducts>
    1642. 

  1642.           <speciesReference species="p" metaid="_651921"/>
    1643. 

  1643.         </listOfProducts>
    1644. 

  1644.         <kineticLaw metaid="_651933">
    1645. 

  1645.           <math xmlns="http://www.w3.org/1998/Math/MathML">          
    1646. 

  1646.             <apply>
    1647. 

  1647.               <times/>
    1648. 

  1648.               <ci> compartment </ci>
    1649. 

  1649.               <ci> k34 </ci>
    1650. 

  1650.               <ci> FREP </ci>
    1651. 

  1651.             </apply>
    1652. 

  1652.           </math>
    1653. 

  1653.         </kineticLaw>
    1654. 

  1654.       </reaction>
    1655. 

  1655.     </listOfReactions>
    1656. 

  1656.   </model>
    1657. 

  1657. </sbml>
    1658.