README 1009 B

12345678910111213141516171819202122
  1. Kraken is a system for assigning taxonomic labels to short DNA
  2. sequences, usually obtained through metagenomic studies. Previous
  3. attempts by other bioinformatics software to accomplish this task have
  4. often used sequence alignment or machine learning techniques that were
  5. quite slow, leading to the development of less sensitive but much faster
  6. abundance estimation programs. Kraken aims to achieve high sensitivity
  7. and high speed by utilizing exact alignments of k-mers and a novel
  8. classification algorithm.
  9. In its fastest mode of operation, for a simulated metagenome of 100 bp
  10. reads, Kraken processed over 4 million reads per minute on a single
  11. core, over 900 times faster than Megablast and over 11 times faster than
  12. the abundance estimation program MetaPhlAn. Kraken's accuracy is
  13. comparable with Megablast, with slightly lower sensitivity and very high
  14. precision.
  15. REFERENCE
  16. Wood DE, Salzberg SL
  17. Kraken: ultrafast metagenomic sequence classification using exact
  18. alignments.
  19. Genome Biology 2014, 15:R46.